Tumor necrosis factor receptor superfamily, member 4 (Q14907610)

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mammalian protein found in Mus musculus

OX40L receptor
OX40 antigen
tumor necrosis factor receptor superfamily member 4
tax-transcriptionally activated glycoprotein 1
Tnfrsf4

Language	Label	Description	Also known as
English	Tumor necrosis factor receptor superfamily, member 4	mammalian protein found in Mus musculus	OX40L receptor OX40 antigen tumor necrosis factor receptor superfamily member 4 tax-transcriptionally activated glycoprotein 1 Tnfrsf4

Statements

1 reference

25 May 2022

UniProt protein ID

tumour necrosis factor receptor 4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47741

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tyrosine-protein kinase ephrin type A/B receptor-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor receptor 4, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

4 references

24 April 2018

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

24 April 2018

Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

24 April 2018

GITR interacts with the pro-apoptotic protein Siva and induces apoptosis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

24 April 2018

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

tumor necrosis factor-activated receptor activity

determination method

1 reference

24 April 2018

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

tumor necrosis factor-activated receptor activity

determination method

protein binding

determination method

5 references

14 February 2019

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

GITR interacts with the pro-apoptotic protein Siva and induces apoptosis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

plasma membrane

determination method

1 reference

14 February 2019

Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

integral component of plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

external side of plasma membrane

determination method

3 references

14 February 2019

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

biological process

regulation of apoptotic process

determination method

1 reference

14 February 2019

The costimulation-regulated duration of PKB activation controls T cell longevity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

negative regulation of activation-induced cell death of T cells

determination method

1 reference

24 April 2018

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

negative regulation of extrinsic apoptotic signaling pathway

determination method

1 reference

24 April 2018

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

24 April 2018

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

multicellular organism development

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

cellular defense response

determination method

1 reference

24 April 2018

Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

response to lipopolysaccharide

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

positive regulation of B cell proliferation

determination method

1 reference

24 April 2018

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

immune response

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

regulation of protein kinase activity

determination method

1 reference

24 April 2018

The costimulation-regulated duration of PKB activation controls T cell longevity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

inflammatory response

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

24 April 2018

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

tumor necrosis factor-mediated signaling pathway

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

T cell proliferation

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47741&geneProductId=UniProtKB:P47741

determination method

inflammatory response

determination method

3 references

14 February 2019

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

The costimulation-regulated duration of PKB activation controls T cell longevity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47741

determination method

positive regulation of B cell proliferation

determination method

negative regulation of DNA-binding transcription factor activity

determination method

negative regulation of transcription, DNA-templated

determination method

TNFR/NGFR cysteine-rich region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47741

tyrosine-protein kinase ephrin type A/B receptor-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47741

Tumour necrosis factor receptor 4, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47741

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000030952

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000030952

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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