The costimulation-regulated duration of PKB activation controls T cell longevity (Q28239478)

Thymoma viral proto-oncogene 1

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Tumor necrosis factor receptor superfamily, member 4

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Glycogen synthase kinase 3 alpha

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author name string

Jianxun Song

1

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Shahram Salek-Ardakani

2

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Paul R Rogers

3

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Mary Cheng

4

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Luk Van Parijs

5

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Michael Croft

The duration of antigenic stimulation determines the fate of naive and effector T cells.

6

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language of work or name

English

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publication date

February 2004

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published in

Nature Immunology

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volume

5

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issue

2

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page(s)

150-8

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cites work

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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

21 January 2018

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The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion.

21 January 2018

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OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

21 January 2018

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4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity

21 January 2018

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

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Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes

21 January 2018

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

21 January 2018

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OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

21 January 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

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Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

21 January 2018

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

21 January 2018

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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

21 January 2018

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Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

21 January 2018

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

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CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

21 January 2018

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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

21 January 2018

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21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

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Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40.

21 January 2018

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Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential

21 January 2018

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Two-photon imaging of lymphocyte motility and antigen response in intact lymph node

21 January 2018

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Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo

21 January 2018

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CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.

21 January 2018

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Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

21 January 2018

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Cell cycle and death control: long live Forkheads

21 January 2018

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Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

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FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

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The CD28 signaling pathway regulates glucose metabolism

21 January 2018

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

21 January 2018

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

21 January 2018

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Control of homeostasis of CD8+ memory T cells by opposing cytokines.

21 January 2018

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Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

21 January 2018

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Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

21 January 2018

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Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Dynamic imaging of T cell-dendritic cell interactions in lymph nodes

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inferred from DOI database lookup

7 January 2021

based on heuristic

A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses

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