TYK2 (Q14914487)

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protein-coding gene in the species Homo sapiens

IMD35
JTK1
tyrosine kinase 2
Non-receptor tyrosine-protein kinase

Language	Label	Description	Also known as
English	TYK2	protein-coding gene in the species Homo sapiens	IMD35 JTK1 tyrosine kinase 2 Non-receptor tyrosine-protein kinase

Statements

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

protein-coding gene

1 reference

Ensembl Release 87

Ensembl gene ID

ENSG00000105397

Protein TYK2 PDB 3LXN.png
1,200 × 1,000; 270 KB

0 references

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

Tyrosine kinase 2

1 reference

6 July 2017

UniProt protein ID

Non-receptor tyrosine-protein kinase TYK2

1 reference

UniProt protein ID

20 March 2016

language of work or name

genetic association

rheumatoid arthritis

determination method

genome-wide association study

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_7148&ncbiId=7297

http://www.genome.gov/gwastudies/index.cfm?gene=TYK2

Genetics of rheumatoid arthritis contributes to biology and drug discovery

25 May 2020

type-1 diabetes

determination method

genome-wide association study

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_9744&ncbiId=7297

http://www.genome.gov/gwastudies/index.cfm?gene=TYK2

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

25 May 2020

determination method

genome-wide association study

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_8893&ncbiId=7297

http://www.genome.gov/gwastudies/index.cfm?gene=TYK2

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

25 May 2020

susceptibility to infection due to TYK2 deficiency

1 reference

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000105397/Orphanet_331226

based on heuristic

inferred from an Open Targets association score over 0.7

human chromosome 19

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

strand orientation

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

10350529

human chromosome 19

genomic assembly

genome assembly GRCh38

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

10461209

human chromosome 19

genomic assembly

Genome assembly GRCh37

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

10491352

human chromosome 19

genomic assembly

Genome assembly GRCh37

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

10380572

human chromosome 19

genomic assembly

genome assembly GRCh38

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

cytogenetic location

19p13.2

1 reference

8 February 2020

20712

1 reference

8 February 2020

Gene Atlas image

PBB GE TYK2 205546 s at fs.png
732 × 530; 11 KB

0 references

1 reference

HomoloGene build68

20712

1 reference

HomoloGene build68

20712

1 reference

HomoloGene build68

20712

anterior pituitary

1

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

right lobe of thyroid gland

2

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

3

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

right uterine tube

4

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

right lobe of liver

5

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

6

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

left lobe of thyroid gland

7

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

upper lobe of left lung

8

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

canal of the cervix

9

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

left uterine tube

10

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000105397

http://identifiers.org/ncbigene/7297

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

8 February 2020

1 reference

7 March 2020

1 reference

8 February 2020

0 references

Ensembl gene ID

ENSG00000105397

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

Ensembl transcript ID

ENST00000592137

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000264818

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000524462

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000524470

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000525220

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000525621

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000525824

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000525976

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000527481

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000529317

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000529370

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000529412

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000529422

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000529739

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000530220

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000530560

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000530829

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000531620

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000531836

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000533334

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

ENST00000534228

1 reference

Ensembl Release 99

Ensembl gene ID

ENSG00000105397

0 references

HGNC gene symbol

1 reference

8 February 2020

1 reference

8 February 2020

Microsoft Academic ID

0 references

1 reference

Online Mendelian Inheritance in Man

19 August 2019

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

based on heuristic

inferred by common HGNC mappings on source and on Wikidata

15 June 2023

Sitelinks

Wikipedia(6 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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