T cell acute lymphocytic leukemia 1 (Q14914630)

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mammalian protein found in Mus musculus
  • stem cell protein
  • Tal1
  • T-cell acute lymphocytic leukemia protein 1 homolog
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Language Label Description Also known as
English
T cell acute lymphocytic leukemia 1
mammalian protein found in Mus musculus
  • stem cell protein
  • Tal1
  • T-cell acute lymphocytic leukemia protein 1 homolog

Statements

molecular function
protein binding
determination method or standard
IPI
10 references
retrieved
14 February 2019
stated in
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
RFP represses transcriptional activation by bHLH transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
More than blood, a novel gene required for mammalian postimplantation development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
retrieved
14 February 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
ISO
6 references
retrieved
21 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
ISO
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IEA
retrieved
21 June 2018
stated in
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
21 June 2018
stated in
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
21 June 2018
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IEA
retrieved
14 February 2019
stated in
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
14 February 2019
stated in
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
14 February 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IBA
biological process
embryonic hemopoiesis
determination method or standard
IMP
5 references
retrieved
14 February 2019
stated in
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
GOA
curator
UniProt
UniProt protein ID
P22091
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IMP
retrieved
14 February 2019
stated in
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IMP
retrieved
14 February 2019
stated in
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IMP
retrieved
14 February 2019
stated in
Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IMP
retrieved
14 February 2019
stated in
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IMP
erythrocyte differentiation
determination method or standard
IDA
IEA
IMP
ISO
5 references
retrieved
27 March 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
ISO
retrieved
27 March 2018
stated in
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IMP
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IEA
retrieved
27 March 2018
stated in
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
27 March 2018
stated in
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P22091&geneProductId=UniProtKB:P22091
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IGI
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
ISO
retrieved
14 February 2019
stated in
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IGI
retrieved
14 February 2019
stated in
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IGI
retrieved
14 February 2019
stated in
LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IGI
retrieved
14 February 2019
stated in
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IGI
retrieved
14 February 2019
stated in
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IEA
erythrocyte differentiation
determination method or standard
IDA
IEA
IMP
ISO
TAS
6 references
retrieved
14 February 2019
stated in
MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
ISO
retrieved
14 February 2019
stated in
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IEA
retrieved
14 February 2019
stated in
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IDA
retrieved
14 February 2019
stated in
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22091
determination method or standard
IDA

Identifiers

 
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