Activin A receptor type 1B (Q1500003)

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mammalian protein found in Homo sapiens

ACTR-IB
ACVR1B
activin receptor-like kinase 4
activin A receptor, type II-like kinase 4
ALK-4
Activin receptor type IB
serine/threonine-protein kinase receptor R2
activin A receptor, type IB
SKR2
activin receptor type-1B

Language	Label	Description	Also known as
English	Activin A receptor type 1B	mammalian protein found in Homo sapiens	ACTR-IB ACVR1B activin receptor-like kinase 4 activin A receptor, type II-like kinase 4 ALK-4 Activin receptor type IB serine/threonine-protein kinase receptor R2 activin A receptor, type IB SKR2 activin receptor type-1B

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

TGFβ superfamily receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

activin types I and II receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

growth factor binding

determination method

1 reference

24 April 2018

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

inhibin binding

determination method

1 reference

8 April 2019

Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

protein binding

determination method

13 references

8 April 2019

Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Roles of pathway-specific and inhibitory Smads in activin receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Activation of signalling by the activin receptor complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

activin-activated receptor activity

determination method

1 reference

8 April 2019

Identification of a functional binding site for activin on the type I receptor ALK4

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

protein serine/threonine kinase activity

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

determination method

1 reference

24 April 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

transforming growth factor beta-activated receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

transforming growth factor beta receptor activity, type I

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

determination method

activin binding

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Identification of a functional binding site for activin on the type I receptor ALK4

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

determination method

2 references

receptor complex

determination method

1 reference

24 April 2018

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

plasma membrane

determination method

2 references

integral component of plasma membrane

determination method

1 reference

24 April 2018

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

activin receptor complex

determination method

1 reference

24 April 2018

Identification of a functional binding site for activin on the type I receptor ALK4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

determination method

1 reference

8 April 2019

Identification of a functional binding site for activin on the type I receptor ALK4

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

integral component of plasma membrane

determination method

biological process

hair follicle development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

positive regulation of erythrocyte differentiation

determination method

1 reference

8 April 2019

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

extrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

in utero embryonic development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

nodal signaling pathway

determination method

1 reference

8 April 2019

Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

positive regulation of trophoblast cell migration

determination method

1 reference

8 April 2019

Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

central nervous system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

development of primary female sexual characteristics

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

positive regulation of activin receptor signaling pathway

determination method

1 reference

8 April 2019

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

regulation of signal transduction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

negative regulation of cell growth

determination method

1 reference

8 April 2019

Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

activin receptor signaling pathway

determination method

3 references

24 April 2018

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

24 April 2018

Roles of pathway-specific and inhibitory Smads in activin receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36896&geneProductId=UniProtKB:P36896

determination method

G1/S transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

pattern specification process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

activin receptor signaling pathway

determination method

4 references

8 April 2019

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Roles of pathway-specific and inhibitory Smads in activin receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36896

determination method

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

activin types I and II receptor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36896

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000257963

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000257963

ENSP00000390477

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390477

ENSP00000397550

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397550

ENSP00000442656

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442656

ENSP00000442885

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442885

ENSP00000443218

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443218

PDB structure ID

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

1 reference

15 October 2015

http://www.uniprot.org/uniprot/Q04771.txt?164

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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