DNA methyltransferase 3B (Q15313478)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88509

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88509

C-5 cytosine methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88509

DNA (cytosine-5)-methyltransferase 3B, ADD domain, protein family

1 reference

PWWP domain, protein family

1 reference

ADD domain, protein family

1 reference

DNA methylase, C-5 cytosine-specific, active site, protein family

1 reference

methyltransferase activity

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

14 February 2019

Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

1 reference

14 February 2019

transcription corepressor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA-methyltransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

1 reference

14 February 2019

protein binding

11 references

14 February 2019

DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Lsh is involved in de novo methylation of DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Lsh controls Hox gene silencing during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA (cytosine-5-)-methyltransferase activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

14 February 2019

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

1 reference

14 February 2019

DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

TAS

1 reference

14 February 2019

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

14 February 2019

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

chromatin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

histone deacetylase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

intracellular membrane-bounded organelle

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

heterochromatin

1 reference

14 February 2019

Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

chromosome, centromeric region

1 reference

14 February 2019

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

nucleus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

14 February 2019

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

regulation of gene expression by genetic imprinting

biological process

1 reference

14 February 2019

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA methylation

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

14 February 2019

methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

1 reference

14 February 2019

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

negative regulation of gene expression, epigenetic

1 reference

14 February 2019

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

positive regulation of histone H3-K4 methylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA methylation-dependent heterochromatin assembly

1 reference

14 February 2019

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

negative regulation of histone H3-K9 methylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

cellular response to amino acid stimulus

1 reference

14 February 2019

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

1 reference

14 February 2019

protein-containing complex localization

1 reference

14 February 2019

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

DNA methylation involved in embryo development

C-5 methylation of cytosine

IEP

1 reference

14 February 2019

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

positive regulation of neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88509