Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases (Q28587647)

31 January 2017

title

Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases (English)

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31 January 2017

main subject

DNA methyltransferase 3B

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GOA release 2020-03-11

author

Albert Jeltsch

series ordinal

2

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author name string

Humaira Gowher

series ordinal

1

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31 January 2017

language of work or name

English

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publication date

7 June 2002

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

277

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31 January 2017

issue

23

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31 January 2017

page(s)

20409–20414

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DNA methylation in health and disease

31 January 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

The role of DNA methylation in mammalian epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

AdoMet-dependent methylation, DNA methyltransferases and base flipping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Cancer epigenetics comes of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Cytosine methylation and human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

The DNA methyltransferases of mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

CpG methylation is maintained in human cancer cells lacking DNMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Protein modelling for all

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Epigenetic reprogramming in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

The DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Hybrid mouse-prokaryotic DNA (cytosine-5) methyltransferases retain the specificity of the parental C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Recombinant Human DNA (Cytosine-5) Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Mouse DNA methyltransferase (MTase) deletion mutants that retain the catalytic domain display neither de novo nor maintenance methylation activity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNA hypomethylation and unusual chromosome instability in cell lines from ICF syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Genetic variation in ICF syndrome: evidence for genetic heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Functional roles of conserved amino acid residues in DNA methyltransferases investigated by site-directed mutagenesis of the EcoRV adenine-N6-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Biotin-avidin microplate assay for the quantitative analysis of enzymatic methylation of DNA by DNA methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Structure and function of DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Methylation patterns of repetitive DNA sequences in germ cells of Mus musculus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Satellite 2 methylation patterns in normal and ICF syndrome cells and association of hypomethylation with advanced replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Number of CpG islands and genes in human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

CpG islands in vertebrate genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200

Cell lineage-specific undermethylation of mouse repetitive DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202148200