Runt-related transcription factor 1 (Q15320472)

Runx, central domain superfamily

1 reference

p53/RUNT-type transcription factor, DNA-binding domain superfamily

1 reference

Runt-related transcription factor RUNX

1 reference

Runx, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Runt domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

10 August 2016

1 reference

10 August 2016

RNA polymerase II transcription regulatory region sequence-specific DNA binding

English

molecular function

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

6 references

14 February 2019

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Twist-2 controls myeloid lineage development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

DNA-binding transcription factor activity, RNA polymerase II-specific

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

DNA-binding transcription factor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

sequence-specific double-stranded DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

promoter-specific chromatin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

5 June 2018

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

intracellular membrane-bounded organelle

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

1 reference

14 February 2019

Dynamic expression of Runx1 in skin affects hair structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

6 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

21 June 2018

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

21 June 2018

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

21 June 2018

Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

protein-containing complex

1 reference

14 February 2019

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

core-binding factor complex

1 reference

14 February 2019

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

cellular response to transforming growth factor beta stimulus

biological process

1 reference

14 February 2019

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

skeletal system development

1 reference

14 February 2019

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

myeloid progenitor cell differentiation

1 reference

14 February 2019

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

chondrocyte differentiation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

response to retinoic acid

1 reference

14 February 2019

Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

positive regulation of interferon-gamma production

1 reference

14 February 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

1 reference

14 February 2019

Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

in utero embryonic development

1 reference

14 February 2019

Runx1 function in hematopoiesis is required in cells that express Tek

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

regulation of hair follicle cell proliferation

1 reference

14 February 2019

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

positive regulation of angiogenesis

IEA

1 reference

14 February 2019

A role for hematopoietic stem cells in promoting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

central nervous system development

1 reference

14 February 2019

Runx1 function in hematopoiesis is required in cells that express Tek

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

behavioral response to pain

1 reference

14 February 2019

Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

regulation of signal transduction

1 reference

14 February 2019

Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons

neuron differentiation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

Runx1 function in hematopoiesis is required in cells that express Tek

embryonic hemopoiesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

positive regulation of cell maturation

1 reference

14 February 2019

Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

hair follicle morphogenesis

1 reference

14 February 2019

Dynamic expression of Runx1 in skin affects hair structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

1 reference

14 February 2019

Runx1 function in hematopoiesis is required in cells that express Tek

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

regulation of T cell anergy

1 reference

14 February 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors

neuron fate commitment

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells

definitive hemopoiesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

positive regulation of transcription by RNA polymerase II

negative regulation of cell population proliferation

1 reference

14 February 2019

Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03347&geneProductId=UniProtKB:Q03347

myeloid cell differentiation

IEA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

negative regulation of granulocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

positive regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

negative regulation of CD4-positive, alpha-beta T cell differentiation

1 reference

14 February 2019

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

positive regulation of CD8-positive, alpha-beta T cell differentiation

1 reference

14 February 2019

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

positive regulation of progesterone secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

3 references

14 February 2019

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03347

has part(s)

Runx, C-terminal domain

1 reference

Runt domain

1 reference

Identifiers

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016