Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit (Q28590672)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

Runt related transcription factor 3

4 November 2019

main subject

1 reference

Runt-related transcription factor 1

GOA release 2020-03-11

1 reference

Runt related transcription factor 2

GOA release 2020-03-11

1 reference

protein heterodimerization activity

GOA release 2020-03-11

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Jerónimo Bravo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

John H Bushweller

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Lina Zhang

1

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Zhe Li

2

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Jiangli Yan

3

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Padmanava Pradhan

4

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Takeshi Corpora

5

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Alan J Warren

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Nancy A Speck

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

language of work or name

English

0 references

publication date

13 June 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

4 November 2019

published in

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

278

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

35

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

33097-33104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

4 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Cbfbeta interacts with Runx2 and has a critical role in bone development

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Causal relationship between the loss of RUNX3 expression and gastric cancer

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Thermodynamic stability of wild-type and mutant p53 core domain

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Solution structure of core binding factor beta and map of the CBF alpha binding site

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Anatomy of hot spots in protein interfaces

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Convergent solutions to binding at a protein-protein interface

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Superadditive and subadditive effects of "hot spot" mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

28 May 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Core-binding factors in haematopoiesis and leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Core-binding factor beta interacts with Runx2 and is required for skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The Runt domain identifies a new family of heteromeric transcriptional regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Overexpression, purification, and biophysical characterization of the heterodimerization domain of the core-binding factor beta subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Identification of the regions involved in DNA binding by the mouse PEBP2alpha protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Cooperative binding of Ets-1 and core binding factor to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Protein functional epitopes: hot spots, dynamics and combinatorial libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Unraveling hot spots in binding interfaces: progress and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Cation-pi interactions in structural biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Molecular basis of leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

DNA-binding by Ig-fold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

Active-site sulfhydryl chemistry plays a major role in the misfolding of urea-denatured rhodanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

18 Systematic mutational analyses of protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303972200

21 January 2018

Identifiers

DOI

10.1074/JBC.M303972200

2 references

Consolidated OpenCitations Corpus – April 2017

1974374

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1974374

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1974374