Gap junction protein, alpha 1 (Q15330604)

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mammalian protein found in Mus musculus
  • Cx43
  • Gja1
  • connexin-43
  • gap junction 43 kDa heart protein
  • gap junction alpha-1 protein
  • alpha 1 connexin
  • gap junction membrane channel protein alpha 1
  • connexin k1
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Language Label Description Also known as
English
Gap junction protein, alpha 1
mammalian protein found in Mus musculus
  • Cx43
  • Gja1
  • connexin-43
  • gap junction 43 kDa heart protein
  • gap junction alpha-1 protein
  • alpha 1 connexin
  • gap junction membrane channel protein alpha 1
  • connexin k1

Statements

molecular function
protein binding
determination method
IPI
12 references
retrieved
24 April 2018
stated in
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function
GOA
curator
UniProt
UniProt protein ID
P23242
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Interaction of connexin43 and protein kinase C-delta during FGF2 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
14-3-3θ facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Connexins modulate autophagosome biogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
retrieved
24 April 2018
stated in
Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IPI
cell component
gap junction
determination method
IDA
IEA
ISO
9 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
ISO
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P23242
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IEA
retrieved
24 April 2018
stated in
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Redistribution of connexin45 in gap junctions of connexin43-deficient hearts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Beating is necessary for transdifferentiation of skeletal muscle‐derived cells into cardiomyocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
intercalated disc
determination method
IDA
IEA
ISO
6 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
ISO
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IEA
retrieved
24 April 2018
stated in
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function
GOA
curator
UniProt
UniProt protein ID
P23242
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
plasma membrane
determination method
IDA
IEA
ISO
7 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
ISO
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P23242
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IEA
retrieved
24 April 2018
stated in
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function
GOA
curator
UniProt
UniProt protein ID
P23242
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
retrieved
24 April 2018
stated in
Regulation of connexin43 protein complexes by intracellular acidification
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P23242&geneProductId=UniProtKB:P23242
determination method
IDA
biological process

Identifiers

 
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