Major prion protein (Q21096129)

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human protein (annotated by UniProtKB/Swiss-Prot P04156)
  • ASCR
  • PrP33-35C
  • PrP27-30
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Language Label Description Also known as
English
Major prion protein
human protein (annotated by UniProtKB/Swiss-Prot P04156)
  • ASCR
  • PrP33-35C
  • PrP27-30

Statements

instance of
protein
0 references
molecular function
copper ion binding
determination method
IDA
TAS
IEA
6 references
stated in
UniProt
UniProt protein ID
P04156
retrieved
4 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
GOA
curator
UniProt
UniProt protein ID
P04156
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
TAS
retrieved
8 April 2019
stated in
Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
TAS
retrieved
8 April 2019
stated in
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IEA
retrieved
8 April 2019
stated in
Molecular features of the copper binding sites in the octarepeat domain of the prion protein
GOA
curator
UniProt
UniProt protein ID
P04156
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IDA
amyloid-beta binding
determination method
IBA
IDA
IEA
IPI
ISS
TAS
7 references
retrieved
8 April 2019
stated in
The Cellular Phase of Alzheimer's Disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
TAS
retrieved
8 April 2019
stated in
Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
ISS
retrieved
8 April 2019
stated in
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IEA
retrieved
8 April 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IBA
protein binding
determination method
IBA
IPI
11 references
retrieved
8 April 2019
stated in
Impact of the cellular prion protein on amyloid-β and 3PO-tau processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Protein microarray analysis identifies human cellular prion protein interactors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Systematic protein-protein interaction mapping for clinically relevant human GPCRs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Novel assay with fluorescence-labelled PrP peptides for differentiating L-type atypical and classical BSEs, and scrapie
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experiment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Characterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IBA
identical protein binding
determination method
IBA
IEA
IMP
IPI
10 references
retrieved
8 April 2019
stated in
Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of human prion protein bound to a therapeutic antibody
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Conformational diversity in prion protein variants influences intermolecular beta-sheet formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experiment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IPI
retrieved
8 April 2019
stated in
Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IBA
cell component
plasma membrane
determination method
IBA
IDA
IEA
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04156
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04156
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IEA
retrieved
8 April 2019
stated in
The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding
GOA
curator
UniProt
UniProt protein ID
P04156
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IDA
retrieved
8 April 2019
stated in
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04156
determination method
IBA
biological process

Identifiers

PDB structure ID
 
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