VAMP associated protein B and C (Q21101169)

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mammalian protein found in Homo sapiens

VAMP-associated 33 kDa protein
vesicle-associated membrane protein-associated protein B/C
VAMP (vesicle-associated membrane protein)-associated protein B and C
VAPB

Language	Label	Description	Also known as
English	VAMP associated protein B and C	mammalian protein found in Homo sapiens	VAMP-associated 33 kDa protein vesicle-associated membrane protein-associated protein B/C VAMP (vesicle-associated membrane protein)-associated protein B and C VAPB

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95292

PapD-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95292

Membrane contact site

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Major sperm protein

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

3 references

8 April 2019

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

microtubule binding

determination method

1 reference

8 April 2019

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

protein binding

determination method

13 references

8 April 2019

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

beta-tubulin binding

determination method

1 reference

8 April 2019

A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

protein heterodimerization activity

determination method

determination method

1 reference

8 April 2019

A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

cadherin binding

determination method

1 reference

27 March 2018

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95292&geneProductId=UniProtKB:O95292

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

endoplasmic reticulum membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

endoplasmic reticulum

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

8 April 2019

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

endoplasmic reticulum exit site

determination method

1 reference

8 April 2019

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

biological process

COPII-coated vesicle budding

determination method

1 reference

8 April 2019

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

sphingolipid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

endoplasmic reticulum organization

determination method

1 reference

8 April 2019

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

positive regulation by host of viral genome replication

determination method

1 reference

27 March 2018

Human VAP-C negatively regulates hepatitis C virus propagation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95292&geneProductId=UniProtKB:O95292

determination method

endoplasmic reticulum to Golgi vesicle-mediated transport

determination method

1 reference

8 April 2019

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

response to unfolded protein

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

suppression of viral release by host

determination method

1 reference

27 March 2018

Human VAP-C negatively regulates hepatitis C virus propagation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95292&geneProductId=UniProtKB:O95292

determination method

negative regulation by host of viral genome replication

determination method

1 reference

27 March 2018

Human VAP-C negatively regulates hepatitis C virus propagation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95292&geneProductId=UniProtKB:O95292

determination method

positive regulation of viral genome replication

determination method

1 reference

8 April 2019

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

negative regulation by virus of viral protein levels in host cell

determination method

1 reference

27 March 2018

Human VAP-C negatively regulates hepatitis C virus propagation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95292&geneProductId=UniProtKB:O95292

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

modulation by host of viral RNA genome replication

determination method

1 reference

27 March 2018

Human VAP-C negatively regulates hepatitis C virus propagation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95292&geneProductId=UniProtKB:O95292

determination method

IRE1-mediated unfolded protein response

determination method

1 reference

8 April 2019

Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95292

determination method

Major sperm protein (MSP) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95292

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000379147

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379147

ENSP00000417175

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417175

ENSP00000430426

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430426

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

0 references

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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