protein tyrosine kinase 2 beta (Q21101275)

Ubiquitin-like domain superfamily

1 reference

Protein kinase-like domain superfamily

1 reference

Protein-tyrosine kinase 2-beta

1 reference

FERM/acyl-CoA-binding protein superfamily

1 reference

PH-like domain superfamily

1 reference

FERM superfamily, second domain

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Band 4.1 domain, protein family

1 reference

FERM central domain, protein family

1 reference

Focal adhesion kinase, targeting (FAT) domain, protein family

1 reference

FERM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

signaling receptor binding

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

2 references

non-membrane spanning protein tyrosine kinase activity

6 references

31 October 2017

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

6 references

8 April 2019

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

3-phosphoinositide-dependent protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

protein tyrosine kinase activity

4 references

8 April 2019

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

ubiquitin protein ligase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

non-membrane spanning protein tyrosine kinase activity

7 references

8 April 2019

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

protein C-terminus binding

1 reference

8 April 2019

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

perinuclear region of cytoplasm

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

cellular response to retinoic acid

biological process

1 reference

8 April 2019

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

adaptive immune response

1 reference

8 April 2019

positive regulation of actin filament polymerization

1 reference

8 April 2019

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

Activation of Pyk2 by stress signals and coupling with JNK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of JNK cascade

1 reference

8 April 2019

Activation of Pyk2 by stress signals and coupling with JNK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

negative regulation of muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

stress fiber assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

negative regulation of ossification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

protein phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

cell surface receptor signaling pathway

1 reference

8 April 2019

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

vascular endothelial growth factor receptor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

3 references

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of cGMP-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

negative regulation of cell population proliferation

1 reference

8 April 2019

Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of actin cytoskeleton reorganization

ISS

positive regulation of protein metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

actin filament organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to reactive oxygen species

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to lithium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to osmotic stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of cell growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of nitric-oxide synthase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to organonitrogen compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of DNA biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of peptidyl-tyrosine phosphorylation

3 references

8 April 2019

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

protein autophosphorylation

1 reference

8 April 2019

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

innate immune response

1 reference

31 October 2017

negative regulation of myeloid cell differentiation

1 reference

8 April 2019

Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to immobilization stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of cell-matrix adhesion

1 reference

8 April 2019

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of JUN kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

immune system process

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

cellular response to fluid shear stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to calcium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

negative regulation of potassium ion transport

1 reference

8 April 2019

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

peptidyl-tyrosine autophosphorylation

4 references

31 October 2017

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

31 October 2017

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

integrin-mediated signaling pathway

1 reference

8 April 2019

Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

response to hydrogen peroxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of leukocyte chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

blood vessel endothelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

activation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of bone mineralization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

31 October 2017

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of cell population proliferation

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

regulation of calcium-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of cell population proliferation

3 references

8 April 2019

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

positive regulation of neuron projection development

1 reference

8 April 2019

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

glial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

3 references

8 April 2019

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

interleukin-7-mediated signaling pathway

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289

regulation of cell adhesion

3 references

8 April 2019

Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

peptidyl-tyrosine autophosphorylation

5 references

8 April 2019

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

interleukin-2-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

regulation of synaptic plasticity

1 reference

8 April 2019

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

protein-containing complex assembly

1 reference

8 April 2019

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137331

has part(s)

Focal adhesion kinase, targeting (FAT) domain

1 reference

tyrosine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Band 4.1 domain

1 reference

FERM central domain

1 reference

FERM domain

1 reference

D08.811.913.696.620.682.725.049.750

Identifiers

MeSH descriptor ID

D051418

subject named as

Focal Adhesion Kinase 2

0 references

MeSH tree code

0 references

D12.776.476.568.049.750

0 references

D23.050.301.500.600.350

0 references

D23.050.705.552.600.350

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference