Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402 (Q22254380)

protein-containing complex assembly

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

T Katagiri

1

T

Katagiri

1 reference

3 April 2023

T Takahashi

2

T

Takahashi

1 reference

3 April 2023

T Sasaki

3

T

Sasaki

1 reference

3 April 2023

S Nakamura

4

S

Nakamura

1 reference

3 April 2023

S Hattori

5

S

Journal of Biological Chemistry

Hattori

1 reference

3 April 2023

language of work or name

English

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publication date

30 June 2000

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published in

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volume

275

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issue

26

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page(s)

19645-52

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JNK is involved in signal integration during costimulation of T lymphocytes.

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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

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Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

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Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

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Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

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Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

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Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling.

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Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades

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FAK and PYK2/CAKbeta in the nervous system: a link between neuronal activity, plasticity and survival?

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Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions

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Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

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Identification of a new Pyk2 target protein with Arf-GAP activity

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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

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Protection from natural killer cell-mediated lysis by HLA-G expression on target cells

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RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes

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Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes

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Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling

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Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

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The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.

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Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

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Costimulation: building an immunological synapse

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

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Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy

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T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A

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Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice

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Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism

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Cytotoxic T lymphocytes express a beta3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK-2

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Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes

21 January 2018

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CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells

21 January 2018

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A p56lck-independent Pathway of CD2 Signaling Involves Jun Kinase

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