RuvB like AAA ATPase 2 (Q21102282)

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mammalian protein found in Homo sapiens

ruvB-like 2
INO80 complex subunit J
erythrocyte cytosolic protein, 51-KD
RuvB (E coli homolog)-like 2
RUVBL2
51 kDa erythrocyte cytosolic protein
Reptin 52
48 kDa TBP-interacting protein
TIP60-associated protein 54-beta
ECP-51
TAP54-beta
reptin52 protein
repressing pontin 52
TIP49b
48 kDa TATA box-binding protein-interacting protein

Language	Label	Description	Also known as
English	RuvB like AAA ATPase 2	mammalian protein found in Homo sapiens	ruvB-like 2 INO80 complex subunit J erythrocyte cytosolic protein, 51-KD RuvB (E coli homolog)-like 2 RUVBL2 51 kDa erythrocyte cytosolic protein Reptin 52 48 kDa TBP-interacting protein TIP60-associated protein 54-beta ECP-51 TAP54-beta reptin52 protein repressing pontin 52 TIP49b 48 kDa TATA box-binding protein-interacting protein

Statements

1 reference

13 November 2019

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y230

RuvB-like helicase 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y230

1 reference

based on heuristic

inferred from protein domain or family

TIP49, P-loop domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

nucleotide binding

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

5'-3' DNA helicase activity

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

helicase activity

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

unfolded protein binding

determination method

1 reference

31 October 2017

Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

DNA helicase activity

determination method

1 reference

31 October 2017

TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

ATPase activity

determination method

1 reference

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

protein binding

determination method

13 references

31 October 2017

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A High-Density Map for Navigating the Human Polycomb Complexome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

identical protein binding

determination method

4 references

31 October 2017

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Large-scale conformational flexibility determines the properties of AAA+ TIP49 ATPases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

chromatin DNA binding

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

hydrolase activity

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

RNA polymerase II core promoter sequence-specific DNA binding

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

TFIID-class transcription factor complex binding

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

protein homodimerization activity

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

NuA4 histone acetyltransferase complex

determination method

intracellular anatomical structure

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

determination method

1 reference

31 October 2017

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

extracellular exosome

determination method

determination method

3 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

ANP32E is a histone chaperone that removes H2A.Z from chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

1 reference

31 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

determination method

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

biological process

chromatin remodeling

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

regulation of transcription, DNA-templated

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

cellular response to UV

determination method

1 reference

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

histone H2A acetylation

determination method

1 reference

31 October 2017

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

cellular response to estradiol stimulus

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

transcription, DNA-templated

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

positive regulation of histone acetylation

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

cellular response to DNA damage stimulus

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

establishment of protein localization to chromatin

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

protein folding

determination method

1 reference

31 October 2017

Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

positive regulation of telomerase RNA localization to Cajal body

determination method

1 reference

31 October 2017

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

histone H4 acetylation

determination method

1 reference

31 October 2017

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

regulation of growth

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

31 October 2017

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

DNA duplex unwinding

determination method

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

box C/D snoRNP assembly

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y230&geneProductId=UniProtKB:Q9Y230

determination method

AAA+ ATPase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y230

TIP49, P-loop domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y230

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000473172

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473172

ENSP00000221413

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000221413

ENSP00000469189

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469189

ENSP00000469488

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469488

ENSP00000469760

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469760

ENSP00000471524

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471524

ENSP00000471538

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471538

ENSP00000486242

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486242

ENSP00000492564

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492564

ENSP00000492610

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492610

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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