Erb-b2 receptor tyrosine kinase 3 (Q21104746)

Tyrosine protein kinase, EGF/ERB/XmrK receptor

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Receptor L-domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Growth factor receptor domain 4, protein family

1 reference

Receptor L-domain, protein family

1 reference

Furin-like cysteine-rich domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Furin-like repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

protein kinase activity

1 reference

8 April 2019

protein tyrosine kinase activator activity

1 reference

8 April 2019

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

protein homodimerization activity

1 reference

8 April 2019

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

29 references

8 April 2019

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Ebp1 isoforms distinctively regulate cell survival and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Pharmacological targeting of the pseudokinase Her3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Oncogenic ERBB3 mutations in human cancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Parallel visualization of multiple protein complexes in individual cells in tumor tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

protein heterodimerization activity

IPI

2 references

transmembrane signaling receptor activity

1 reference

8 April 2019

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

5 June 2018

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

ubiquitin protein ligase binding

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IPI

receptor tyrosine kinase

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

neuregulin receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

transmembrane receptor protein tyrosine kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

protein tyrosine kinase activity

1 reference

8 April 2019

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

cell component

lateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

2 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

integral component of plasma membrane

1 reference

5 June 2018

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

basolateral plasma membrane

1 reference

8 April 2019

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

intracellular anatomical structure

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

1 reference

8 April 2019

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

integral component of plasma membrane

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

basal plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

3 references

8 April 2019

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway

biological process

neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

negative regulation of cell adhesion

IMP

1 reference

8 April 2019

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

endocardial cushion development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of protein tyrosine kinase activity

1 reference

8 April 2019

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

8 April 2019

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of calcineurin-NFAT signaling cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

ISS

protein phosphorylation

1 reference

8 April 2019

negative regulation of secretion

1 reference

8 April 2019

ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

regulation of cell population proliferation

1 reference

8 April 2019

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

phosphatidylinositol 3-kinase signaling

IMP

1 reference

8 April 2019

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

negative regulation of signal transduction

1 reference

8 April 2019

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

1 reference

8 April 2019

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

phosphatidylinositol phosphate biosynthetic process

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

regulation of cell motility

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

ERBB2 signaling pathway

1 reference

8 April 2019

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of cardiac muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of protein kinase B signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

negative regulation of signal transduction

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

negative regulation of apoptotic process

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

positive regulation of ERK1 and ERK2 cascade

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860

transmembrane receptor protein tyrosine kinase signaling pathway

3 references

8 April 2019

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

nervous system development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

positive regulation of cell population proliferation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545154

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2408045

has part(s)

protein kinase domain

1 reference

Growth factor receptor domain 4

1 reference

Receptor L-domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Furin-like repeat

1 reference

Furin-like cysteine-rich domain

1 reference

D08.811.913.696.620.682.725.400.009.500

Identifiers

MeSH descriptor ID

D020893

subject named as

Receptor, ErbB-3

0 references

MeSH tree code

0 references

D12.776.543.750.630.009.500

0 references

D12.776.543.750.750.400.074.500

0 references

D12.776.624.664.700.790

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference