PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer (Q24338724)

identical protein binding

GOA release 2020-03-11

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GOA release 2020-03-11

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1 reference

V Serra

1

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Josep Baselga

17

object named as

J Baselga

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author name string

M Scaltriti

2

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L Prudkin

3

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P J A Eichhorn

4

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Y H Ibrahim

5

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S Chandarlapaty

6

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B Markman

7

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O Rodriguez

8

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M Guzman

9

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S Rodriguez

10

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M Gili

11

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M Russillo

12

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J L Parra

13

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S Singh

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J Arribas

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N Rosen

The PI3K pathway as drug target in human cancer

16

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language of work or name

English

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publication date

2 June 2011

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published in

Oncogene

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volume

30

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page(s)

2547-57

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issue

22

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cites work

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

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Defining the role of mTOR in cancer

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

19 March 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

19 March 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 April 2017

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

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PIK3CA mutation associates with improved outcome in breast cancer.

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In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

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PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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30 May 2018

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The first-in-human study of the hydrogen sulfate (Hyd-sulfate) capsule of the MEK1/2 inhibitor AZD6244 (ARRY-142886): a phase I open-label multicenter trial in patients with advanced cancer

30 May 2018

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Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer

21 January 2018

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Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163.

21 January 2018

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21 January 2018

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Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

21 January 2018

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

29 November 2018

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Promoter methylation of the PTEN gene is a common molecular change in breast cancer

31 March 2020

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Gastrosplenic fistula from Hodgkin's lymphoma

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2010.626

1 reference

Dimensions Publication ID

1823225

1006324258

0 references

1823225

1 reference

1 reference

1 reference