Protection of telomeres 1 (Q21104947)

Protection of telomeres protein 1

1 reference

Telomeric single stranded DNA binding POT1/Cdc13, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protection of telomeres protein 1, ssDNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

5 December 2018

1 reference

5 December 2018

2 references

telomeric DNA binding

1 reference

8 April 2019

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

single-stranded telomeric DNA binding

4 references

8 April 2019

POT1 as a terminal transducer of TRF1 telomere length control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

DEAD/H-box RNA helicase binding

1 reference

8 April 2019

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

14 references

8 April 2019

POT1 as a terminal transducer of TRF1 telomere length control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

POT1 association with TRF2 regulates telomere length

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The human CST complex is a terminator of telomerase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

PTOP interacts with POT1 and regulates its localization to telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

POT1 and TRF2 cooperate to maintain telomeric integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

G-rich strand telomeric DNA binding

IPI

3 references

17 October 2017

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

17 October 2017

The human CST complex is a terminator of telomerase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

17 October 2017

Characterization of the DNA binding specificity of Shelterin complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

telomerase inhibitor activity

1 reference

17 October 2017

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

G-rich single-stranded DNA binding

1 reference

8 April 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

telomeric D-loop binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

telomeric G-quadruplex DNA binding

1 reference

8 April 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8-hydroxy-2'-deoxyguanosine DNA binding

1 reference

8 April 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

G-rich strand telomeric DNA binding

4 references

8 April 2019

The human CST complex is a terminator of telomerase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Characterization of the DNA binding specificity of Shelterin complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

nuclear telomere cap complex

IBA

cell component

1 reference

17 October 2017

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

4 references

8 April 2019

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Characterization of the DNA binding specificity of Shelterin complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

negative regulation of telomerase activity

biological process

1 reference

17 October 2017

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

1 reference

8 April 2019

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

positive regulation of helicase activity

1 reference

8 April 2019

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

positive regulation of telomerase activity

3 references

8 April 2019

PTOP interacts with POT1 and regulates its localization to telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

establishment of protein localization to telomere

1 reference

8 April 2019

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

1 reference

8 April 2019

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

positive regulation of DNA strand elongation

1 reference

8 April 2019

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

17 October 2017

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

17 October 2017

POT1 and TRF2 cooperate to maintain telomeric integrity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

17 October 2017

Telomere protection by mammalian Pot1 requires interaction with Tpp1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

regulation of DNA helicase activity

IGI

1 reference

8 April 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

positive regulation of DNA helicase activity

1 reference

8 April 2019

Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

telomeric D-loop disassembly

1 reference

8 April 2019

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

telomere maintenance via telomerase

IGI

1 reference

8 April 2019

POT1 as a terminal transducer of TRF1 telomere length control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

regulation of telomere maintenance via telomerase

1 reference

17 October 2017

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5

positive regulation of telomere maintenance via telomerase

IGI

3 references

8 April 2019

Human POT1 facilitates telomere elongation by telomerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

POT1 as a terminal transducer of TRF1 telomere length control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

The POT1-TPP1 telomere complex is a telomerase processivity factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

POT1 and TRF2 cooperate to maintain telomeric integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Telomere protection by mammalian Pot1 requires interaction with Tpp1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5

Telomeric single stranded DNA binding POT1/Cdc13

IBA

has part(s)

1 reference

Protection of telomeres protein 1, ssDNA-binding domain

1 reference