POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates (Q24308828)

positive regulation of helicase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

6

Thomas R Cech

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Patricia L Opresko

object named as

Patricia L Opresko

1

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Elaine R Podell

3

object named as

Elaine R Podell

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Vilhelm A. Bohr

7

object named as

Vilhelm A Bohr

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author name string

Penelope A Mason

2

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Ming Lei

4

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Ian D Hickson

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

16 September 2005

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published in

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volume

280

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issue

37

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page(s)

32069-80

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cites work

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Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

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Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein

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Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

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Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

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Mammalian telomeres end in a large duplex loop

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Control of human telomere length by TRF1 and TRF2

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Control of telomere length by the human telomeric protein TRF1

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Pot1, the putative telomere end-binding protein in fission yeast and humans

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

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Human POT1 facilitates telomere elongation by telomerase

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POT1 as a terminal transducer of TRF1 telomere length control

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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

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DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites

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T-loops and the origin of telomeres

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Telomere biology: a new player in the end zone.

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

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Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase

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Global expression changes resulting from loss of telomeric DNA in fission yeast

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The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

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Functional and physical interaction between WRN helicase and human replication protein A

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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

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Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

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The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity

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DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA

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Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

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Oligomeric ring structure of the Bloom's syndrome helicase

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Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

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Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases

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Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

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The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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Junction of RecQ helicase biochemistry and human disease.

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Regulation of WRN helicase activity in human base excision repair

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Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

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The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis

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Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function

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Telomere maintenance by recombination in human cells.

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Alternative lengthening of telomeres in mammalian cells

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Loss of hPot1 function leads to telomere instability and a cut-like phenotype

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POT1 and TRF2 cooperate to maintain telomeric integrity

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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

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Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

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