NIMA related kinase 2 (Q21105225)

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mammalian protein found in Homo sapiens
  • nimA-related protein kinase 2
  • nimA-like protein kinase 1
  • protein phosphatase 1, regulatory subunit 111
  • Never in mitosis A-related kinase 2
  • NIMA (never in mitosis gene a)-related kinase 2
  • serine/threonine-protein kinase Nek2
  • HSPK 21
  • NEK2
  • NEK2A
  • NEK2 protein, human
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Language Label Description Also known as
English
NIMA related kinase 2
mammalian protein found in Homo sapiens
  • nimA-related protein kinase 2
  • nimA-like protein kinase 1
  • protein phosphatase 1, regulatory subunit 111
  • Never in mitosis A-related kinase 2
  • NIMA (never in mitosis gene a)-related kinase 2
  • serine/threonine-protein kinase Nek2
  • HSPK 21
  • NEK2
  • NEK2A
  • NEK2 protein, human

Statements

molecular function
protein kinase activity
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IEA
retrieved
8 April 2019
stated in
beta-Catenin is a Nek2 substrate involved in centrosome separation
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IDA
retrieved
8 April 2019
stated in
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IDA
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
beta-Catenin is a Nek2 substrate involved in centrosome separation
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion
GOA
curator
UniProt
UniProt protein ID
P51955
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
retrieved
8 April 2019
stated in
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51955
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
C089441
subject named as
NEK2 protein, human
0 references
PDB structure ID
 
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