Reticulon 4 (Q21106505)

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mammalian protein found in Homo sapiens

neurite growth inhibitor 220
NSP
Nogo protein
RTN-x
neurite outgrowth inhibitor
foocen
My043 protein
RTN4
Neuroendocrine-specific protein
reticulon 5
neuroendocrine-specific protein C homolog
Human NogoA
Reticulon-5
reticulon-4

Language	Label	Description	Also known as
English	Reticulon 4	mammalian protein found in Homo sapiens	neurite growth inhibitor 220 NSP Nogo protein RTN-x neurite outgrowth inhibitor foocen My043 protein RTN4 Neuroendocrine-specific protein reticulon 5 neuroendocrine-specific protein C homolog Human NogoA Reticulon-5 reticulon-4

Statements

1 reference

13 November 2019

UniProt protein ID

Reticulon domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

6 references

8 April 2019

A class of dynamin-like GTPases involved in the generation of the tubular ER network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

determination method

1 reference

31 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

cadherin binding

determination method

1 reference

31 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

determination method

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

cell projection

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

nuclear envelope

determination method

1 reference

8 April 2019

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

integral component of endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum

determination method

5 references

31 October 2017

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

31 October 2017

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

31 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum membrane

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Identification and characterization of TMEM33 as a reticulon-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

plasma membrane

determination method

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

extracellular exosome

determination method

1 reference

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum tubular network

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum tubular network membrane

determination method

1 reference

8 April 2019

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum

determination method

5 references

8 April 2019

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

8 April 2019

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

plasma membrane

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

biological process

nuclear pore complex assembly

determination method

1 reference

8 April 2019

Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

regulation of apoptotic process

determination method

1 reference

8 April 2019

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

cardiac epithelial to mesenchymal transition

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

apoptotic process

determination method

1 reference

8 April 2019

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

negative regulation of axonogenesis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

regulation of nervous system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum tubular network organization

determination method

regulation of cell migration

determination method

1 reference

31 October 2017

A new role for Nogo as a regulator of vascular remodeling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC3&geneProductId=UniProtKB:Q9NQC3

determination method

negative regulation of cell growth

determination method

1 reference

8 April 2019

LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

axonal fasciculation

determination method

3 references

positive regulation of epithelial cell migration

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

positive regulation of mammary gland epithelial cell proliferation

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

positive regulation of protein localization to endoplasmic reticulum

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

positive regulation of ERBB3 signaling pathway

determination method

1 reference

8 April 2019

The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

endoplasmic reticulum tubular network membrane organization

determination method

1 reference

8 April 2019

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

blastocyst formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

cellular sphingolipid homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC3

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NQC3

Identifiers

RefSeq protein ID

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000322147

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000322147

ENSP00000337838

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000337838

ENSP00000349944

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349944

ENSP00000350365

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350365

ENSP00000378107

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378107

ENSP00000378109

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378109

ENSP00000384471

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384471

ENSP00000385650

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385650

ENSP00000384825

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384825

ENSP00000397808

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397808

ENSP00000411628

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411628

ENSP00000489133

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489133

PDB structure ID

1 reference

UniProt protein ID

8 August 2016

language of work or name

1 reference

UniProt protein ID

8 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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