Gamma-aminobutyric acid type B receptor subunit 2 (Q21107529)

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mammalian protein found in Homo sapiens

gamma-aminobutyric acid B receptor 2
GABBR2
G-protein coupled receptor 51
GABA-B receptor, R2 subunit
GABA-B receptor 2
gb2
GABA-B-R2
gamma-aminobutyric acid (GABA) B receptor, 2
HG20
gamma-aminobutyric acid type B receptor subunit 2
GABA-BR2

Language	Label	Description	Also known as
English	Gamma-aminobutyric acid type B receptor subunit 2	mammalian protein found in Homo sapiens	gamma-aminobutyric acid B receptor 2 GABBR2 G-protein coupled receptor 51 GABA-B receptor, R2 subunit GABA-B receptor 2 gb2 GABA-B-R2 gamma-aminobutyric acid (GABA) B receptor, 2 HG20 gamma-aminobutyric acid type B receptor subunit 2 GABA-BR2

Statements

1 reference

13 November 2019

UniProt protein ID

GPCR family 3, gamma-aminobutyric acid receptor, type B2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75899

Periplasmic binding protein-like I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75899

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75899

G protein-coupled receptor

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Receptor, ligand binding region, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR family 3, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 3, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

3 references

8 April 2019

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

Structural mechanism of ligand activation in human GABAB receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

G protein-coupled GABA receptor activity

determination method

3 references

5 June 2018

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75899&geneProductId=UniProtKB:O75899

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75899&geneProductId=UniProtKB:O75899

determination method

5 June 2018

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75899&geneProductId=UniProtKB:O75899

determination method

signal transducer activity

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75899&geneProductId=UniProtKB:O75899

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

G protein-coupled GABA receptor activity

determination method

4 references

8 April 2019

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

neuron projection

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

G protein-coupled receptor heterodimeric complex

determination method

1 reference

5 June 2018

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75899&geneProductId=UniProtKB:O75899

determination method

plasma membrane

determination method

2 references

postsynaptic membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

integral component of plasma membrane

determination method

3 references

8 April 2019

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

GABA receptor complex

determination method

1 reference

8 April 2019

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

biological process

gamma-aminobutyric acid signaling pathway

determination method

1 reference

5 June 2018

Heterodimerization is required for the formation of a functional GABA(B) receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75899&geneProductId=UniProtKB:O75899

determination method

G protein-coupled receptor signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

Heterodimerization is required for the formation of a functional GABA(B) receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

negative regulation of adenylate cyclase activity

determination method

1 reference

8 April 2019

Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

chemical synaptic transmission

determination method

1 reference

8 April 2019

Heterodimerization is required for the formation of a functional GABA(B) receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

neuron-glial cell signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75899

determination method

physically interacts with

arbaclofen placarbil

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107312

4-hydroxybutyric acid

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1342

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL301742

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL112797

Receptor, ligand binding region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75899

GPCR, family 3, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75899

GPCR family 3, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75899

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000259455

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000259455

ENSP00000489352

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489352

ENSP00000490789

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490789

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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