Structural mechanism of ligand activation in human GABAB receptor (Q27680758)

1

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Martin Bush

2

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Lidia Mosyak

3

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Feng Wang

4

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Qing R Fan

Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2

5

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language of work or name

English

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publication date

12 December 2013

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published in

Nature

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volume

504

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issue

7479

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page(s)

254-9

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cites work

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

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Heterodimerization is required for the formation of a functional GABA(B) receptor

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Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity

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A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor

20 March 2017

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Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

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Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit

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Trans-activation between 7TM domains: implication in heterodimeric GABABreceptor activation

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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.

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Activation mechanism of the heterodimeric GABA(B) receptor

29 September 2017

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Molecular structure and physiological functions of GABA(B) receptors

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Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

29 September 2017

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The activation mechanism of class-C G-protein coupled receptors

29 September 2017

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Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.

29 September 2017

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29 September 2017

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No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.

29 September 2017

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29 September 2017

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Ligand-induced signal transduction within heterodimeric GABA(B) receptor

29 September 2017

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Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors

29 September 2017

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C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

29 September 2017

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A trafficking checkpoint controls GABA(B) receptor heterodimerization

29 September 2017

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Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1.

29 September 2017

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Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding

29 September 2017

1 reference

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Role of heteromer formation in GABAB receptor function

29 September 2017

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GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

29 September 2017

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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

29 September 2017

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Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1.

29 September 2017

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The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

29 September 2017

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Chemistry and pharmacology of GABAB receptor ligands

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12725

Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12725

The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12725

Baculovirus expression system for heterologous multiprotein complexes.

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12725

The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12725

GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen

21 January 2018

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Modelling prior distributions of atoms for macromolecular refinement and completion.

21 January 2018

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Evaluation of protein fold comparison servers

21 January 2018

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Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil alpha-helices

21 January 2018

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12 December 2020

Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors

1 reference

12 December 2020

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer

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12 December 2020

Metabotropic glutamate receptor 5 is a disulfide-linked dimer

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12 December 2020

Identifiers

DOI

10.1038/NATURE12725

1 reference

Dimensions Publication ID

1019654534

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Fatcat ID

release_og52efpjcbd3jgsfcnrdpt47mu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/og52efpjcbd3jgsfcnrdpt47mu

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

24305054

1 reference