Growth arrest and DNA damage inducible alpha (Q21108143)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

DDIT-1
growth arrest and DNA damage-inducible protein GADD45 alpha
DNA damage-inducible transcript 1 protein
DNA damage-inducible transcript-1
growth arrest and DNA-damage-inducible 45 alpha
GADD45A

Language	Label	Description	Also known as
English	Growth arrest and DNA damage inducible alpha	mammalian protein found in Homo sapiens	DDIT-1 growth arrest and DNA damage-inducible protein GADD45 alpha DNA damage-inducible transcript 1 protein DNA damage-inducible transcript-1 growth arrest and DNA-damage-inducible 45 alpha GADD45A

Statements

1 reference

13 November 2019

UniProt protein ID

50S ribosomal protein L30e-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24522

Growth arrest and DNA damage-inducible protein GADD45

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24522

Ribosomal protein L7Ae/L30e/S12e/Gadd45, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

9 references

8 April 2019

TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

determination method

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

protein N-terminus binding

determination method

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

RNA polymerase II core promoter sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

determination method

1 reference

16 July 2018

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

determination method

5 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

16 July 2018

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

biological process

apoptotic process

determination method

1 reference

8 April 2019

Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

centrosome cycle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

regulation of cyclin-dependent protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

negative regulation of protein kinase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

signal transduction in response to DNA damage

determination method

1 reference

8 April 2019

Feedback between p21 and reactive oxygen production is necessary for cell senescence

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

response to stress

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method

positive regulation of JNK cascade

determination method

1 reference

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

cellular response to mechanical stimulus

determination method

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

positive regulation of reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

Feedback between p21 and reactive oxygen production is necessary for cell senescence

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

cellular response to ionizing radiation

determination method

1 reference

8 April 2019

Feedback between p21 and reactive oxygen production is necessary for cell senescence

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

determination method

1 reference

8 April 2019

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

positive regulation of p38MAPK cascade

determination method

1 reference

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method

regulation of cell cycle

determination method

Ribosomal protein L7Ae/L30e/S12e/Gadd45

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24522

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000360024

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360024

ENSP00000360025

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360025

ENSP00000482814

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482814

ENSP00000497697

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497697

ENSP00000496875

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496875

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21108143&oldid=2022932297"