Damage specific DNA binding protein 1 (Q21108214)

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mammalian protein found in Homo sapiens
  • UV-damaged DNA-binding factor
  • DNA damage-binding protein a
  • damage-specific DNA binding protein 1, 127kDa
  • XPE-BF
  • UV-damaged DNA-binding protein 1
  • DDB1
  • DDBa
  • XAP-1
  • HBV X-associated protein 1
  • DNA damage-binding protein 1
  • UV-DDB 1
  • XPE-binding factor
  • DDB p127 subunit
  • Damage-specific DNA-binding protein 1
  • xeroderma pigmentosum group E-complementing protein
  • XPCe
edit
Language Label Description Also known as
English
Damage specific DNA binding protein 1
mammalian protein found in Homo sapiens
  • UV-damaged DNA-binding factor
  • DNA damage-binding protein a
  • damage-specific DNA binding protein 1, 127kDa
  • XPE-BF
  • UV-damaged DNA-binding protein 1
  • DDB1
  • DDBa
  • XAP-1
  • HBV X-associated protein 1
  • DNA damage-binding protein 1
  • UV-DDB 1
  • XPE-binding factor
  • DDB p127 subunit
  • Damage-specific DNA-binding protein 1
  • xeroderma pigmentosum group E-complementing protein
  • XPCe

Statements

molecular function
protein binding
determination method
IPI
31 references
retrieved
8 April 2019
stated in
Identification of a primary target of thalidomide teratogenicity
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Selective degradation of splicing factor CAPERĪ± by anticancer sulfonamides
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Lenalidomide induces ubiquitination and degradation of CK1Ī± in del(5q) MDS.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of lenalidomide-induced CK1Ī± degradation by the CRL4(CRBN) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Viral immune modulators perturb the human molecular network by common and unique strategies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
retrieved
8 April 2019
stated in
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
GOA
curator
Developmental FunctionaL Annotation at Tufts
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IPI
cell component
Cul4A-RING E3 ubiquitin ligase complex
determination method
IDA
5 references
retrieved
8 April 2019
stated in
Identification of a primary target of thalidomide teratogenicity
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IDA
retrieved
8 April 2019
stated in
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IDA
retrieved
8 April 2019
stated in
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IDA
retrieved
8 April 2019
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IDA
retrieved
8 April 2019
stated in
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
GOA
curator
UniProt
UniProt protein ID
Q16531
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
determination method
IDA
biological process

Identifiers

PDB structure ID
 
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