VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity (Q24299516)

GOA release 2020-03-11

8

Pawel Ciborowski

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author name string

Michele D Kassmeier

1

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Koushik Mondal

2

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Victoria L Palmer

3

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Prafulla Raval

4

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Sushil Kumar

5

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Greg A Perry

6

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Dirk K Anderson

7

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Sarah Jackson

9

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Yue Xiong

10

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Patrick C Swanson

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

11

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language of work or name

English

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publication date

15 February 2012

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published in

The EMBO Journal

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volume

31

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issue

4

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page(s)

945-58

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cites work

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The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining

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VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation

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Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo

19 March 2017

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Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

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Autoubiquitylation of the V(D)J recombinase protein RAG1

19 March 2017

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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Mechanistic constraints on diversity in human V(D)J recombination

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Expression and V(D)J recombination activity of mutated RAG-1 proteins

19 March 2017

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RAG-1-deficient mice have no mature B and T lymphocytes

19 March 2017

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

19 March 2017

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The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3.

19 March 2017

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The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.

27 September 2017

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Temporal and spatial regulatory functions of the V(D)J recombinase

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Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase

27 September 2017

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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development

27 September 2017

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Evidence for Ku70/Ku80 association with full-length RAG1.

27 September 2017

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The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

27 September 2017

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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

27 September 2017

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Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome

27 September 2017

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Testing gene function early in the B cell lineage in mb1-cre mice

27 September 2017

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Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis

27 September 2017

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Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice

27 September 2017

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Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

27 September 2017

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V(D)J recombination: RAG proteins, repair factors, and regulation

27 September 2017

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Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP.

27 September 2017

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Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination

27 September 2017

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Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription

27 September 2017

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RAG and HMGB1 proteins: purification and biochemical analysis of recombination signal complexes.

27 September 2017

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Pre-steady-state kinetic studies of the fidelity and mechanism of polymerization catalyzed by truncated human DNA polymerase lambda

21 January 2018

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Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4+:CD8+ T-cell ratios are reversed by smoking cessation: influence of bone mass on immune cell response to and recovery from smoke exposure.

21 January 2018

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Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2011.455

RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation

21 January 2018

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V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

21 January 2018

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Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

21 January 2018

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Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei

29 November 2018

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12 December 2020

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

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12 December 2020

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice

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Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

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Regions of RAG1 protein critical for V(D)J recombination

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12 December 2020

A zinc-binding domain involved in the dimerization of RAG1

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Biochemical and folding defects in a RAG1 variant associated with Omenn syndrome

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12 December 2020