L3MBTL1, histone methyl-lysine binding protein (Q21108711)

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mammalian protein found in Homo sapiens

L3MBTL1
lethal(3)malignant brain tumor-like protein 1
l(3)mbt-like 1
l(3)mbt protein homolog
lethal (3) malignant brain tumor l(3)

Language	Label	Description	Also known as
English	L3MBTL1, histone methyl-lysine binding protein	mammalian protein found in Homo sapiens	L3MBTL1 lethal(3)malignant brain tumor-like protein 1 l(3)mbt-like 1 l(3)mbt protein homolog lethal (3) malignant brain tumor l(3)

Statements

1 reference

20 December 2017

UniProt protein ID

Zinc finger, C2HC-type superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y468

Mbt repeat domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, C2H2C-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

20 December 2017

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

molecular function

DNA-binding transcription factor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

zinc ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

SAM domain binding

determination method

1 reference

9 May 2019

The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

chromatin binding

determination method

1 reference

9 May 2019

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

methylated histone binding

determination method

5 references

9 May 2019

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

L3MBTL1, a histone-methylation-dependent chromatin lock

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

protein binding

determination method

7 references

9 May 2019

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Methylation of the retinoblastoma tumor suppressor by SMYD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Tudor, MBT and chromo domains gauge the degree of lysine methylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

L3MBTL1, a histone-methylation-dependent chromatin lock

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

identical protein binding

determination method

1 reference

9 May 2019

The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

nucleosome binding

determination method

1 reference

9 May 2019

L3MBTL1, a histone-methylation-dependent chromatin lock

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

plasma membrane

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

determination method

1 reference

9 May 2019

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

determination method

1 reference

9 May 2019

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

condensed chromosome

determination method

1 reference

9 May 2019

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

L3MBTL1, a histone-methylation-dependent chromatin lock

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y468&geneProductId=UniProtKB:Q9Y468

determination method

regulation of cell cycle

determination method

1 reference

9 May 2019

Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

negative regulation of transcription, DNA-templated

determination method

4 references

9 May 2019

The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

9 May 2019

L3MBTL1, a histone-methylation-dependent chromatin lock

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

regulation of megakaryocyte differentiation

determination method

1 reference

9 May 2019

PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

regulation of mitotic nuclear division

determination method

1 reference

9 May 2019

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

regulation of signal transduction by p53 class mediator

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

determination method

1 reference

9 May 2019

Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y468

determination method

Zinc finger, C2HC-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y468

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y468

Identifiers

RefSeq protein ID

1 reference

6 January 2018

1 reference

6 January 2018

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

Ensembl protein ID

ENSP00000362227

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000362227

ENSP00000398516

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000398516

ENSP00000402107

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000402107

ENSP00000362226

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000362226

ENSP00000387971

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000387971

ENSP00000410139

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000410139

ENSP00000412938

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000412938

ENSP00000415971

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000415971

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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