Serine/threonine kinase 11 (Q21109306)

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mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase STK11
  • serine/threonine-protein kinase 11
  • polarization-related protein LKB1
  • hLKB1
  • STK11
  • serine/threonine-protein kinase LKB1
  • liver kinase B1
  • renal carcinoma antigen NY-REN-19
  • LKB1
  • STK11 protein, human
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Language Label Description Also known as
English
Serine/threonine kinase 11
mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase STK11
  • serine/threonine-protein kinase 11
  • polarization-related protein LKB1
  • hLKB1
  • STK11
  • serine/threonine-protein kinase LKB1
  • liver kinase B1
  • renal carcinoma antigen NY-REN-19
  • LKB1
  • STK11 protein, human

Statements

molecular function
protein serine/threonine kinase activity
determination method
IDA
TAS
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
TAS
retrieved
8 April 2019
stated in
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IEA
retrieved
8 April 2019
stated in
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
retrieved
8 April 2019
stated in
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
retrieved
8 April 2019
stated in
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
protein binding
determination method
IPI
17 references
retrieved
8 April 2019
stated in
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IPI
cell component
cytoplasm
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IEA
retrieved
8 April 2019
stated in
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
retrieved
8 April 2019
stated in
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of an alternative splice variant of LKB1
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
retrieved
8 April 2019
stated in
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction
GOA
curator
UniProt
UniProt protein ID
Q15831
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
C109790
subject named as
STK11 protein, human
0 references
 
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