Characterization of an alternative splice variant of LKB1 (Q24322647)

STE20-related kinase adaptor alpha

GOA release 2020-03-11

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Calcium binding protein 39

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Fiona C Denison

1

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Natalie J Hiscock

2

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David Carling

3

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Angela Woods

Journal of Biological Chemistry

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language of work or name

English

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publication date

2 January 2009

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published in

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volume

284

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issue

1

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page(s)

67-76

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cites work

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

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Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

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Analysis of the LKB1-STRAD-MO25 complex

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Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

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Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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The regulation of AMP-activated protein kinase by phosphorylation

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

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Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro

21 January 2018

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

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LKB1-dependent signaling pathways

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

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Calcineurin is required for translational control of protein synthesis in rat pancreatic acini

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LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

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LKB1/STRAD promotes axon initiation during neuronal polarization.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro

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Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay

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Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation

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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

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The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

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Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation

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STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

21 January 2018

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Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo

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Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells

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A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

21 January 2018

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Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

21 January 2018

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