P21 (RAC1) activated kinase 4 (Q21109711)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O96013

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O96013

p21 activated kinase binding domain, protein family

1 reference

CRIB domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

1 reference

8 April 2019

protein kinase activity

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

1 reference

8 April 2019

protein binding

6 references

8 April 2019

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

SH3RF2 functions as an oncogene by mediating PAK4 protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

A human MAP kinase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

Group I and II mammalian PAKs have different modes of activation by Cdc42

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

cadherin binding involved in cell-cell adhesion

1 reference

26 September 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

26 September 2017

26 September 2017

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

protein serine/threonine kinase activity

MicroRNA-24 regulates vascularity after myocardial infarction

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

8 April 2019

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

cadherin binding involved in cell-cell adhesion

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

1 reference

26 September 2017

Golgi apparatus

1 reference

8 April 2019

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

focal adhesion

1 reference

26 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

focal adhesion

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

biological process

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

1 reference

8 April 2019

cellular response to organic cyclic compound

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

1 reference

8 April 2019

cell growth

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

dendritic spine development

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

cytoskeleton organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

1 reference

8 April 2019

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

cell migration

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

cell-cell adhesion

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

Rho protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

1 reference

26 September 2017

regulation of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

1 reference

26 September 2017

signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

actin cytoskeleton organization

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

1 reference

26 September 2017

stress-activated protein kinase signaling cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

activation of protein kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=O96013&geneProductId=UniProtKB:O96013

1 reference

26 September 2017

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

regulation of cell growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

positive regulation of angiogenesis

1 reference

8 April 2019

MicroRNA-24 regulates vascularity after myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

negative regulation of endothelial cell apoptotic process

1 reference

8 April 2019

MicroRNA-24 regulates vascularity after myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96013

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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4 August 2016

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4 August 2016