The emerging importance of group II PAKs (Q24294885)

P21 (RAC1) activated kinase 5

Europe PubMed Central

title

The emerging importance of group II PAKs (English)

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main subject

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BUB1B-PAK6 readthrough

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P21 (RAC1) activated kinase 4

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cell migration

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Cell migration: integrating signals from front to back

author

Gareth E. Jones

series ordinal

2

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author name string

Claire M Wells

series ordinal

1

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language of work or name

English

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publication date

1 February 2010

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published in

Biochemical Journal

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volume

425

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issue

3

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page(s)

465-73

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cites work

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p21-activated kinases in cancer

20 April 2017

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Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

20 April 2017

1 reference

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

20 April 2017

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PAK4 mediates morphological changes through the regulation of GEF-H1

20 April 2017

1 reference

P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration

20 April 2017

1 reference

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

20 April 2017

1 reference

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

20 April 2017

1 reference

A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF

20 April 2017

1 reference

Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain

20 April 2017

1 reference

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

20 April 2017

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Activated PAK4 regulates cell adhesion and anchorage-independent growth

20 April 2017

1 reference

Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase

20 April 2017

1 reference

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

20 April 2017

1 reference

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

20 April 2017

1 reference

Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties

20 April 2017

1 reference

Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6

20 April 2017

1 reference

Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase

20 April 2017

1 reference

Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor

20 April 2017

1 reference

Inhibition of myosin light chain kinase by p21-activated kinase

20 April 2017

1 reference

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

20 April 2017

1 reference

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

20 April 2017

1 reference

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin

20 April 2017

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Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin

20 April 2017

1 reference

PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

20 April 2017

1 reference

IQGAP proteins are integral components of cytoskeletal regulation

20 April 2017

1 reference

Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins

20 April 2017

1 reference

Apoptosis: a review of programmed cell death

20 April 2017

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

20 April 2017

1 reference

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

20 April 2017

1 reference

PAK3 mutation in nonsyndromic X-linked mental retardation

20 April 2017

1 reference

The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration

20 April 2017

1 reference

PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin

20 April 2017

1 reference

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

20 April 2017

1 reference

Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells

20 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

20 April 2017

1 reference

p21-activated kinases: three more join the Pak.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Multiple Rho proteins regulate the subcellular targeting of PAK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Identification of an autoinhibitory domain of p21-activated protein kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

PAK4 is activated via PI3K in HGF-stimulated epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Mechanism of p21-activated Kinase 6-mediated Inhibition of Androgen Receptor Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Targeting group II PAKs in cancer and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Xenopus p21-activated kinase 5 regulates blastomeres' adhesive properties during convergent extension movements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Targeted disruption of the gene for the PAK5 kinase in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

21 January 2018

Cofilin takes the lead.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Polarised migration: cofilin holds the front.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

How is actin polymerization nucleated in vivo?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Roles of microtubules, cell polarity and adhesion in electric-field-mediated motility of 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Microtubules meet substrate adhesions to arrange cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Counter-regulatory function of protein tyrosine phosphatase 1B in platelet-derived growth factor- or fibroblast growth factor-induced motility and proliferation of cultured smooth muscle cells and in neointima formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

p21 activated kinase 5 activates Raf-1 and targets it to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Williams syndrome and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

alpha-Synuclein affects the MAPK pathway and accelerates cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

ROCK, PAK, and Toll of synapses in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

WASP and WIP regulate podosomes in migrating leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Probing the human kinome for kinases involved in pancreatic cancer cell survival and gemcitabine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Survey of differentially methylated promoters in prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Mechanisms of the development of androgen independence in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

Biological properties and gene expression associated with metastatic potential of human osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

7 January 2021

Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

7 January 2021

Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

7 January 2021

Gene expression profiles in gallbladder cancer: the close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

7 January 2021

AR and ER interaction with a p21-activated kinase (PAK6)

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091173

7 January 2021