Pre-mRNA processing factor 19 (Q21109719)

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mammalian protein found in Homo sapiens

PRP19/PSO4 homolog
RING-type E3 ubiquitin transferase PRP19
senescence evasion factor
PRPF19
nuclear matrix protein NMP200 related to splicing factor PRP19
psoralen 4
hPso4
pre-mRNA-processing factor 19
nuclear matrix protein 200
PRP19/PSO4 pre-mRNA processing factor 19 homolog

Language	Label	Description	Also known as
English	Pre-mRNA processing factor 19	mammalian protein found in Homo sapiens	PRP19/PSO4 homolog RING-type E3 ubiquitin transferase PRP19 senescence evasion factor PRPF19 nuclear matrix protein NMP200 related to splicing factor PRP19 psoralen 4 hPso4 pre-mRNA-processing factor 19 nuclear matrix protein 200 PRP19/PSO4 pre-mRNA processing factor 19 homolog

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

Pre-mRNA-processing factor 19

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

U box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pre-mRNA-splicing factor 19, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ricin B, lectin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

G-protein beta WD-40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ubiquitin protein ligase activity

determination method

ubiquitin-protein transferase activity

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

ubiquitin-ubiquitin ligase activity

determination method

1 reference

8 April 2019

U box proteins as a new family of ubiquitin-protein ligases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

protein binding

determination method

10 references

8 April 2019

Molecular architecture of the human Prp19/CDC5L complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

identical protein binding

determination method

1 reference

8 April 2019

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

ubiquitin protein ligase activity

determination method

3 references

8 April 2019

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

U box proteins as a new family of ubiquitin-protein ligases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

site of double-strand break

determination method

1 reference

8 April 2019

Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

3 references

8 April 2019

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

catalytic step 2 spliceosome

determination method

1 reference

31 October 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

determination method

1 reference

31 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

1 reference

31 October 2017

Molecular architecture of the human Prp19/CDC5L complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

DNA replication factor A complex

determination method

1 reference

8 April 2019

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

spliceosomal complex

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

U box proteins as a new family of ubiquitin-protein ligases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

2 references

U2-type catalytic step 1 spliceosome

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Molecular architecture of the human Prp19/CDC5L complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

U2-type catalytic step 2 spliceosome

determination method

1 reference

8 April 2019

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

biological process

mRNA splicing, via spliceosome

determination method

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

31 October 2017

Molecular architecture of the human Prp19/CDC5L complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

31 October 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

spliceosomal tri-snRNP complex assembly

determination method

1 reference

8 April 2019

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

lipid biosynthetic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

negative regulation of neuron differentiation

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMS4&geneProductId=UniProtKB:Q9UMS4

determination method

positive regulation of astrocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

positive regulation of mRNA splicing, via spliceosome

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

protein K63-linked ubiquitination

determination method

mRNA processing

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

protein polyubiquitination

determination method

1 reference

8 April 2019

U box proteins as a new family of ubiquitin-protein ligases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

inner cell mass cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

spliceosomal complex assembly

determination method

1 reference

8 April 2019

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

transcription-coupled nucleotide-excision repair

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

double-strand break repair via nonhomologous end joining

determination method

1 reference

8 April 2019

Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

generation of catalytic spliceosome for first transesterification step

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

mRNA splicing, via spliceosome

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Molecular architecture of the human Prp19/CDC5L complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

8 April 2019

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

positive regulation of neuron differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMS4

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

G-protein beta WD-40 repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

Ricin B, lectin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

Pre-mRNA-splicing factor 19

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

WD40 repeat, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMS4

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000227524

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000227524

ENSP00000440266

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440266

ENSP00000443031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443031

ENSP00000445435

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445435

ENSP00000446259

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446259

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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