Tankyrase 2 (Q21111137)

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mammalian protein found in Homo sapiens
  • ADP-ribosyltransferase diphtheria toxin-like 6
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  • poly [ADP-ribose] polymerase 5B
  • tankyrase II
  • poly [ADP-ribose] polymerase tankyrase-2
  • protein poly-ADP-ribosyltransferase tankyrase-2
  • tankyrase-2
  • TNKS2
  • ARTD6
  • tankyrase-related protein
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  • tankyrase-like protein
  • TNKS-2
edit
Language Label Description Also known as
English
Tankyrase 2
mammalian protein found in Homo sapiens
  • ADP-ribosyltransferase diphtheria toxin-like 6
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  • poly [ADP-ribose] polymerase 5B
  • tankyrase II
  • poly [ADP-ribose] polymerase tankyrase-2
  • protein poly-ADP-ribosyltransferase tankyrase-2
  • tankyrase-2
  • TNKS2
  • ARTD6
  • tankyrase-related protein
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  • tankyrase-like protein
  • TNKS-2

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
retrieved
8 April 2019
stated in
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IPI
NAD+ ADP-ribosyltransferase activity
determination method
IDA
TAS
IEA
6 references
retrieved
24 April 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2
determination method
TAS
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2
determination method
IEA
retrieved
24 April 2018
stated in
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2
determination method
IDA
retrieved
24 April 2018
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2
determination method
IDA
retrieved
24 April 2018
stated in
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H2K2&geneProductId=UniProtKB:Q9H2K2
determination method
IDA
NAD+ ADP-ribosyltransferase activity
determination method
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IEA
retrieved
8 April 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IDA
retrieved
8 April 2019
stated in
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
GOA
curator
UniProt
UniProt protein ID
Q9H2K2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IDA
retrieved
8 April 2019
stated in
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H2K2
determination method
IBA
cell component
biological process

Identifiers

PDB structure ID
 
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