Metadherin (Q21111259)

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mammalian protein found in Homo sapiens

astrocyte elevated gene-1 protein
lysine-rich CEACAM1 co-isolated protein
3D3/LYRIC
astrocyte elevated gene 1
protein LYRIC
AEG-1
metastasis adhesion protein
MTDH

Language	Label	Description	Also known as
English	Metadherin	mammalian protein found in Homo sapiens	astrocyte elevated gene-1 protein lysine-rich CEACAM1 co-isolated protein 3D3/LYRIC astrocyte elevated gene 1 protein LYRIC AEG-1 metastasis adhesion protein MTDH

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86UE4

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription coactivator activity

determination method

1 reference

8 April 2019

Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

NF-kappaB binding

determination method

1 reference

26 September 2017

Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86UE4&geneProductId=UniProtKB:Q86UE4

determination method

protein binding

determination method

6 references

8 April 2019

Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

double-stranded RNA binding

determination method

1 reference

8 April 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

determination method

1 reference

8 April 2019

Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

nuclear membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

endoplasmic reticulum membrane

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

bicellular tight junction

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

endoplasmic reticulum

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

perinuclear region of cytoplasm

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

fibrillar center

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

endoplasmic reticulum membrane

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

biological process

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

positive regulation of autophagy

determination method

1 reference

8 April 2019

Astrocyte elevated gene-1 induces protective autophagy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

bicellular tight junction assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

8 April 2019

Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

lipopolysaccharide-mediated signaling pathway

determination method

1 reference

8 April 2019

Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

positive regulation of nucleic acid-templated transcription

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86UE4

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000338235

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000338235

ENSP00000428168

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428168

ENSP00000428703

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428703

ENSP00000429289

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429289

ENSP00000429642

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429642

PDB structure ID

1 reference

UniProt protein ID

19 March 2016

language of work or name

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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