DExH-box helicase 58 (Q21111268)

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mammalian protein found in Homo sapiens

DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
probable ATP-dependent helicase LGP2
RLR
ortholog of mouse D11lgp2
RNA helicase LGP2
RLR-3
protein D11Lgp2 homolog
probable ATP-dependent RNA helicase DHX58
RIG-I-like receptor LGP2
RIG-I-like receptor 3

Language	Label	Description	Also known as
English	DExH-box helicase 58	mammalian protein found in Homo sapiens	DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 probable ATP-dependent helicase LGP2 RLR ortholog of mouse D11lgp2 RNA helicase LGP2 RLR-3 protein D11Lgp2 homolog probable ATP-dependent RNA helicase DHX58 RIG-I-like receptor LGP2 RIG-I-like receptor 3

Statements

1 reference

13 November 2019

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96C10

RIG-I-like receptor, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96C10

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase/UvrB, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

RIG-I-like receptor, C-terminal regulatory domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

nucleotide binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

helicase activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

zinc ion binding

determination method

1 reference

1 January 2018

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

metal ion binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

protein binding

determination method

5 references

1 January 2018

DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

1 January 2018

A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

1 January 2018

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

1 January 2018

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

1 January 2018

A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

single-stranded RNA binding

determination method

1 reference

1 January 2018

Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

hydrolase activity

determination method

2 references

determination method

2 references

biological process

negative regulation of MDA-5 signaling pathway

determination method

1 reference

1 January 2018

RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

regulation of innate immune response

determination method

1 reference

1 January 2018

Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

immune system process

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

defense response to virus

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

innate immune response

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

negative regulation of RIG-I signaling pathway

determination method

3 references

1 January 2018

RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

1 January 2018

Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

response to bacterium

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C10

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000251642

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000251642

ENSP00000404639

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404639

ENSP00000416389

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416389

ENSP00000466721

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466721

ENSP00000467470

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467470

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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