AlkB homolog 5, RNA demethylase (Q21111313)

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mammalian protein found in Homo sapiens

AlkB family member 5, RNA demethylase
RNA demethylase ALKBH5
alkB, alkylation repair homolog 5
alkylated DNA repair protein alkB homolog 5
oxoglutarate and iron-dependent oxygenase domain containing
alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
probable alpha-ketoglutarate-dependent dioxygenase ABH5
ALKBH5

Language	Label	Description	Also known as
English	AlkB homolog 5, RNA demethylase	mammalian protein found in Homo sapiens	AlkB family member 5, RNA demethylase RNA demethylase ALKBH5 alkB, alkylation repair homolog 5 alkylated DNA repair protein alkB homolog 5 oxoglutarate and iron-dependent oxygenase domain containing alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 probable alpha-ketoglutarate-dependent dioxygenase ABH5 ALKBH5

Statements

1 reference

13 November 2019

UniProt protein ID

Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P6C2

RNA demethylase ALKBH5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P6C2

Alpha-ketoglutarate-dependent dioxygenase AlkB-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

2-oxoglutarate-dependent dioxygenase activity

determination method or standard

1 reference

8 April 2019

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

oxidoreductase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

dioxygenase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

oxidative RNA demethylase activity

determination method or standard

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

26 September 2017

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

determination method or standard

oxidative RNA demethylase activity

determination method or standard

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

mRNA N6-methyladenosine dioxygenase activity

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

oxidative RNA demethylase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

Golgi apparatus

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

biological process

cell differentiation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

response to hypoxia

determination method or standard

1 reference

8 April 2019

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

mRNA export from nucleus

determination method or standard

1 reference

26 September 2017

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6P6C2&geneProductId=UniProtKB:Q6P6C2

determination method or standard

spermatogenesis

determination method or standard

DNA dealkylation involved in DNA repair

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

mRNA processing

determination method or standard

3 references

8 April 2019

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

oxidative single-stranded RNA demethylation

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

regulation of mRNA stability

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P6C2

determination method or standard

Alpha-ketoglutarate-dependent dioxygenase AlkB-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6P6C2

Identifiers

MeSH descriptor ID

subject named as

AlkB Homolog 5, RNA Demethylase

0 references

D08.811.074.062.937

0 references

D08.811.682.662.582.207

0 references

D08.811.682.690.416.139.968

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000382091

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382091

ENSP00000468116

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468116

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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