SLC9A3 regulator 1 (Q21112493)

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mammalian protein found in Homo sapiens
  • Sodium-hydrogen exchanger regulatory factor 1
  • Ezrin-radixin-moesin-binding phosphoprotein 50
  • regulatory cofactor of Na(+)/H(+) exchanger
  • Na(+)/H(+) exchange regulatory cofactor NHE-RF1
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
  • EBP50
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
  • solute carrier family 9 isoform A3 regulatory factor 1
  • Na+/H+ exchange regulatory co-factor
  • ezrin-radixin-moesin binding phosphoprotein-50
  • SLC9A3R1
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Language Label Description Also known as
English
SLC9A3 regulator 1
mammalian protein found in Homo sapiens
  • Sodium-hydrogen exchanger regulatory factor 1
  • Ezrin-radixin-moesin-binding phosphoprotein 50
  • regulatory cofactor of Na(+)/H(+) exchanger
  • Na(+)/H(+) exchange regulatory cofactor NHE-RF1
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
  • EBP50
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
  • solute carrier family 9 isoform A3 regulatory factor 1
  • Na+/H+ exchange regulatory co-factor
  • ezrin-radixin-moesin binding phosphoprotein-50
  • SLC9A3R1

Statements

molecular function
protein binding
determination method
IPI
26 references
retrieved
9 May 2019
stated in
The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal cell carcinoma through recruiting Rac1 guanine nucleotide exchange factor ARHGEF7
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for NHERF recognition by ERM proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
A novel association of mGluR1a with the PDZ scaffold protein CAL modulates receptor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
retrieved
9 May 2019
stated in
PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14745
determination method
IPI
cell component
extracellular exosome
determination method
IDA
5 references
retrieved
17 October 2017
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14745&geneProductId=UniProtKB:O14745
determination method
IDA
retrieved
17 October 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14745&geneProductId=UniProtKB:O14745
determination method
IDA
retrieved
17 October 2017
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14745&geneProductId=UniProtKB:O14745
determination method
IDA
retrieved
17 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14745&geneProductId=UniProtKB:O14745
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
O14745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14745&geneProductId=UniProtKB:O14745
determination method
IDA
biological process

Identifiers

PDB structure ID
 
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