Chromobox 5 (Q21112513)

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mammalian protein found in Homo sapiens
  • CBX5
  • HP1 alpha
  • HP1Hs alpha
  • HP1 alpha homolog
  • chromobox protein homolog 5
  • heterochromatin protein 1-alpha
  • HP1-ALPHA
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • epididymis luminal protein 25
  • antigen p25
  • heterochromatin protein 1 homolog alpha
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Language Label Description Also known as
English
Chromobox 5
mammalian protein found in Homo sapiens
  • CBX5
  • HP1 alpha
  • HP1Hs alpha
  • HP1 alpha homolog
  • chromobox protein homolog 5
  • heterochromatin protein 1-alpha
  • HP1-ALPHA
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • epididymis luminal protein 25
  • antigen p25
  • heterochromatin protein 1 homolog alpha

Statements

molecular function
protein binding
determination method
IPI
33 references
retrieved
8 April 2019
stated in
Human BAHD1 promotes heterochromatic gene silencing
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Chromatin components as part of a putative transcriptional repressing complex
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of the human HP1 interactome reveals novel binding partners
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Heterochromatin links to centromeric protection by recruiting shugoshin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Tudor, MBT and chromo domains gauge the degree of lysine methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Chromatin components as part of a putative transcriptional repressing complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IPI
cell component
nucleus
determination method
IEA
IDA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IEA
retrieved
8 April 2019
stated in
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IDA
retrieved
8 April 2019
stated in
Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
GOA
curator
UniProt
UniProt protein ID
P45973
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IDA
retrieved
8 April 2019
stated in
Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
D000090266
subject named as
Chromobox Protein Homolog 5
0 references
 
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