JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin (Q24318979)

methylated histone binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Tony Kouzarides

7

0 references

Mark A. Dawson

Mark A Dawson

1

0 references

Andrew Bannister

Andrew J Bannister

2

0 references

Samuel D Foster

Samuel D Foster

4

0 references

Anthony R Green

Anthony R Green

6

0 references

Berthold Gottgens

3

Berthold Göttgens

0 references

author name string

Till Bartke

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

5

0 references

language of work or name

English

0 references

publication date

8 October 2009

0 references

published in

Nature

0 references

volume

461

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page(s)

819-22

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issue

7265

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cites work

1 reference

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Chromatin modifications and their function

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

19 March 2017

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

19 March 2017

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

19 March 2017

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

19 March 2017

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

7 April 2017

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

7 April 2017

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Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells.

7 April 2017

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JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

27 September 2017

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Chromatin structure regulates gene conversion

27 September 2017

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Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

27 September 2017

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

27 September 2017

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JAK signaling globally counteracts heterochromatic gene silencing

27 September 2017

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Activated Jak2 with the V617F point mutation promotes G1/S phase transition

27 September 2017

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JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders

27 September 2017

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Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency

27 September 2017

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Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis

27 September 2017

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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

27 September 2017

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Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation

27 September 2017

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The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.

27 September 2017

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Heterochromatin links to centromeric protection by recruiting shugoshin

27 September 2017

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HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation

30 May 2018

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Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

30 May 2018

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The role of jak2a in zebrafish hematopoiesis.

30 May 2018

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TFBScluster: a resource for the characterization of transcriptional regulatory networks

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19783980

12 December 2020

inferred from PubMed ID database lookup

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19783980

12 December 2020

inferred from PubMed ID database lookup

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

JAK mutations in high-risk childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Reconstitution of nucleosome core particles from recombinant histones and DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

The CBP co-activator is a histone acetyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Initiation of human DNA replication in vitro using nuclei from cells arrested at an initiation-competent state.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Rb targets histone H3 methylation and HP1 to promoters

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08448

7 January 2021

Identifiers

DOI

10.1038/NATURE08448

1 reference

Dimensions Publication ID

3097531

1049642587

0 references

3097531

1 reference

1 reference

1 reference