RAB1A, member RAS oncogene family (Q21113198)

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mammalian protein found in Homo sapiens

GTP binding protein Rab1a
YPT1-related protein
ras-related protein Rab-1A
RAB1A
RAB1, member RAS oncogene family
Rab GTPase YPT1 homolog

Language	Label	Description	Also known as
English	RAB1A, member RAS oncogene family	mammalian protein found in Homo sapiens	GTP binding protein Rab1a YPT1-related protein ras-related protein Rab-1A RAB1A RAB1, member RAS oncogene family Rab GTPase YPT1 homolog

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62820

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62820

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

2 references

protein binding

determination method

9 references

8 April 2019

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Identification and characterization of Iporin as a novel interaction partner for rab1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Rab1A is an mTORC1 activator and a colorectal oncogene

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

cadherin binding

determination method

1 reference

31 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

GTPase activity

determination method

4 references

31 October 2017

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

GTPase activity

determination method

5 references

8 April 2019

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

Golgi apparatus

determination method

3 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

extracellular exosome

determination method

1 reference

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

transport vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

Golgi apparatus

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

biological process

COPII-coated vesicle cargo loading

determination method

1 reference

8 April 2019

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

1 reference

8 April 2019

Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

establishment of endothelial intestinal barrier

determination method

1 reference

8 April 2019

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

Golgi organization

determination method

1 reference

8 April 2019

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

vesicle transport along microtubule

determination method

1 reference

8 April 2019

Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

autophagosome assembly

determination method

1 reference

31 October 2017

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

positive regulation of glycoprotein metabolic process

determination method

1 reference

8 April 2019

Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

endoplasmic reticulum to Golgi vesicle-mediated transport

determination method

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

31 October 2017

Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

COPII vesicle coating

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

melanosome transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

growth hormone secretion

determination method

1 reference

8 April 2019

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

defense response to bacterium

determination method

1 reference

8 April 2019

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

protein transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

substrate adhesion-dependent cell spreading

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

cilium assembly

determination method

1 reference

8 April 2019

Functional dissection of Rab GTPases involved in primary cilium formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

positive regulation of ubiquitin protein ligase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

post-translational protein modification

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62820&geneProductId=UniProtKB:P62820

determination method

intracellular protein transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

endoplasmic reticulum to Golgi vesicle-mediated transport

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

Rab protein signal transduction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62820

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

small GTP-binding protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62820

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000381540

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381540

ENSP00000386451

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386451

ENSP00000387286

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387286

ENSP00000386672

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386672

ENSP00000497078

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497078

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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