Rab1A is an mTORC1 activator and a colorectal oncogene (Q24307749)

2

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Yue-Hua Wei

3

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Jun-Hung Cho

4

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Laura E Morris

5

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Hui-Yun Wang

6

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X F Steven Zheng

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

7

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language of work or name

English

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publication date

10 November 2014

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published in

Cancer Cell

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volume

26

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issue

5

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page(s)

754-69

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cites work

1 reference

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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

19 March 2017

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Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

19 March 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

19 March 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

19 March 2017

1 reference

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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

19 March 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

19 March 2017

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

19 March 2017

1 reference

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

19 March 2017

1 reference

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Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

19 March 2017

1 reference

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Leucyl-tRNA synthetase controls TORC1 via the EGO complex

19 March 2017

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The Vam6 GEF controls TORC1 by activating the EGO complex

19 March 2017

1 reference

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Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.

19 March 2017

1 reference

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Dual prenylation is required for Rab protein localization and function

19 March 2017

1 reference

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Functional discovery via a compendium of expression profiles

19 March 2017

1 reference

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The 14-3-3 proteins positively regulate rapamycin-sensitive signaling

19 March 2017

1 reference

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Rab GTPases as coordinators of vesicle traffic

19 March 2017

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The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

19 March 2017

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Localization of Rheb to the endomembrane is critical for its signaling function

19 March 2017

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Rab GTPases Are Recruited to Chlamydial Inclusions in Both a Species-Dependent and Species-Independent Manner

19 March 2017

1 reference

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

19 March 2017

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

19 March 2017

1 reference

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Role of Rab GTPases in membrane traffic and cell physiology

19 March 2017

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

7 April 2017

1 reference

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Regulation of TORC1 by Rag GTPases in nutrient response

7 April 2017

1 reference

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

7 April 2017

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The TOR pathway: a target for cancer therapy

7 April 2017

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mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

7 April 2017

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The TOR complex 1 is a direct target of Rho1 GTPase

27 September 2017

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Target of rapamycin (TOR) in nutrient signaling and growth control

27 September 2017

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Maf1 regulation: a model of signal transduction inside the nucleus

27 September 2017

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Recent Clinical Trials of mTOR-Targeted Cancer Therapies

27 September 2017

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Regulation of mTORC1 by the Rab and Arf GTPases

27 September 2017

1 reference

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Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling

27 September 2017

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Nutrient signals driving cell growth.

27 September 2017

1 reference

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How Saccharomyces responds to nutrients

27 September 2017

1 reference

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Targeting mammalian target of rapamycin (mTOR) for health and diseases.

27 September 2017

1 reference

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Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin

27 September 2017

1 reference

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

27 September 2017

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Aberrant expression of RAB1A in human tongue cancer.

27 September 2017

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How cells coordinate growth and division

27 September 2017

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COPI recruitment is modulated by a Rab1b-dependent mechanism

27 September 2017

1 reference

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Membrane targeting of Rab GTPases is influenced by the prenylation motif

27 September 2017

1 reference

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Smart drugs: tyrosine kinase inhibitors in cancer therapy

27 September 2017

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A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

27 September 2017

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Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

27 September 2017

1 reference

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Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport

27 September 2017

1 reference

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Tumorigenic and metastatic properties of "normal" and ras-transfected NIH/3T3 cells

27 September 2017

1 reference

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Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

27 September 2017

1 reference

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4288827

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4288827

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4288827

Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy

29 November 2018

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