Large tumor suppressor kinase 1 (Q21114061)

http://www.ebi.ac.uk/interpro/protein/O95835

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95835

Serine/threonine-protein kinase LATS1

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95835

Ubiquitin-associated domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

23 references

8 April 2019

Ajuba LIM proteins are negative regulators of the Hippo signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Tumor suppressor LATS1 is a negative regulator of oncogene YAP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Molecular characterization of human homologs of yeast MOB1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

AMPK modulates Hippo pathway activity to regulate energy homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Molecular characterization of human homologs of yeast MOB1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

IPI

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

IPI

protein kinase activity

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

magnesium ion binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

protein serine/threonine kinase activity

5 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

estrogen receptor binding

1 reference

8 April 2019

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

protein serine/threonine kinase activity

IPI

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

microtubule organizing center

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

31 January 2018

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

G2/M transition of mitotic cell cycle

1 reference

8 April 2019

Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

regulation of actin filament polymerization

1 reference

8 April 2019

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

inner cell mass cell fate commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

keratinocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

regulation of organ growth

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

regulation of protein-containing complex assembly

1 reference

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

cytoplasmic sequestering of protein

1 reference

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

sister chromatid segregation

1 reference

8 April 2019

Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

positive regulation of apoptotic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

negative regulation of canonical Wnt signaling pathway

1 reference

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

inner cell mass cellular morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

4 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

31 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95835&geneProductId=UniProtKB:O95835

regulation of intracellular estrogen receptor signaling pathway

1 reference

8 April 2019

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

mammary gland epithelial cell differentiation

1 reference

8 April 2019

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

peptidyl-serine phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835

intracellular signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95835