Protein tyrosine kinase 6 (Q21114361)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

PTK6, SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

protein kinase activity

1 reference

8 April 2019

non-membrane spanning protein tyrosine kinase activity

3 references

24 April 2018

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882

24 April 2018

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

9 references

8 April 2019

Regulated association of protein kinase B/Akt with breast tumor kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Identification of STAT3 as a specific substrate of breast tumor kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

identical protein binding

IPI

3 references

8 April 2019

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

signaling receptor binding

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

2 references

protein tyrosine kinase activity

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Identification of STAT3 as a specific substrate of breast tumor kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

non-membrane spanning protein tyrosine kinase activity

EXP

4 references

8 April 2019

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

cellular response to retinoic acid

IDA

biological process

1 reference

8 April 2019

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

negative regulation of growth

IMP

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

negative regulation of protein tyrosine kinase activity

1 reference

8 April 2019

Regulated association of protein kinase B/Akt with breast tumor kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

regulation of cell population proliferation

IDA

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882

intestinal epithelial cell differentiation

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882

positive regulation of neuron projection development

1 reference

8 April 2019

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

peptidyl-tyrosine autophosphorylation

IMP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

protein autophosphorylation

1 reference

8 April 2019

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882

IMP

innate immune response

1 reference

24 April 2018

1 reference

8 April 2019

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

positive regulation of cell cycle

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

ERBB2 signaling pathway

1 reference

8 April 2019

negative regulation of signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

positive regulation of epidermal growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882

tyrosine-protein kinase, active site

has part(s)

1 reference

SH3 domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

PTK6, SH2 domain

1 reference