NAD(P)H quinone dehydrogenase 1 (Q21114701)

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mammalian protein found in Homo sapiens

phylloquinone reductase
menadione reductase
NAD(P)H:menadione oxidoreductase 1
diaphorase-4
NAD(P)H dehydrogenase [quinone] 1
azoreductase
quinone reductase 1
NQO1
NAD(P)H:Quinone acceptor oxidoreductase type 1
DTD
DT-diaphorase
QR1
NAD(P)H:quinone oxidoreductase 1
dioxin-inducible 1
NAD(P)H dehydrogenase, quinone 1
diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
NAD(P)H:quinone oxireductase

Language	Label	Description	Also known as
English	NAD(P)H quinone dehydrogenase 1	mammalian protein found in Homo sapiens	phylloquinone reductase menadione reductase NAD(P)H:menadione oxidoreductase 1 diaphorase-4 NAD(P)H dehydrogenase [quinone] 1 azoreductase quinone reductase 1 NQO1 NAD(P)H:Quinone acceptor oxidoreductase type 1 DTD DT-diaphorase QR1 NAD(P)H:quinone oxidoreductase 1 dioxin-inducible 1 NAD(P)H dehydrogenase, quinone 1 diaphorase (NADH/NADPH) (cytochrome b-5 reductase) NAD(P)H:quinone oxireductase

Statements

1 reference

13 November 2019

UniProt protein ID

Flavoprotein-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15559

Flavodoxin-like fold, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

superoxide dismutase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

cytochrome-b5 reductase activity, acting on NAD(P)H

determination method

1 reference

8 April 2019

Infracortical interstitial cells concurrently expressing m2-muscarinic receptors, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate-diaphorase in the human and monkey cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

identical protein binding

determination method

1 reference

8 April 2019

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

oxidoreductase activity

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

NAD(P)H dehydrogenase (quinone) activity

determination method

3 references

31 October 2017

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

determination method

1 reference

31 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

determination method

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

NAD(P)H dehydrogenase (quinone) activity

determination method

4 references

8 April 2019

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

electron transfer activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

extracellular exosome

determination method

1 reference

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

determination method

3 references

8 April 2019

Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

determination method

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

31 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

31 October 2017

Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15559&geneProductId=UniProtKB:P15559

determination method

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

biological process

response to estradiol

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

negative regulation of catalytic activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

nitric oxide biosynthetic process

determination method

1 reference

8 April 2019

Infracortical interstitial cells concurrently expressing m2-muscarinic receptors, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate-diaphorase in the human and monkey cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

regulation of cellular amino acid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to organic cyclic compound

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to nutrient

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

removal of superoxide radicals

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

synaptic transmission, cholinergic

determination method

1 reference

8 April 2019

Infracortical interstitial cells concurrently expressing m2-muscarinic receptors, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate-diaphorase in the human and monkey cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to oxidative stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

xenobiotic metabolic process

determination method

1 reference

8 April 2019

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to ethanol

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to toxic substance

determination method

1 reference

8 April 2019

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

superoxide metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to electrical stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

cellular response to metal ion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

electron transport chain

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

cellular response to hydrogen peroxide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to nitrogen compound

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

response to hydrogen sulfide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15559

determination method

Flavodoxin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15559

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000319788

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000319788

ENSP00000368334

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368334

ENSP00000368335

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368335

ENSP00000398330

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000398330

ENSP00000455020

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000455020

ENSP00000456282

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456282

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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