SHC adaptor protein 1 (Q21116165)

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mammalian protein found in Homo sapiens
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC1
  • SHC-transforming protein A
  • SHC-transforming protein 1
  • SHC-transforming protein 3
  • Src homology 2 domain-containing-transforming protein C1
  • SH2 domain protein C1
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Language Label Description Also known as
English
SHC adaptor protein 1
mammalian protein found in Homo sapiens
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC1
  • SHC-transforming protein A
  • SHC-transforming protein 1
  • SHC-transforming protein 3
  • Src homology 2 domain-containing-transforming protein C1
  • SH2 domain protein C1

Statements

molecular function
protein binding
determination method
IPI
40 references
retrieved
8 April 2019
stated in
Temporal regulation of EGF signalling networks by the scaffold protein Shc1
GOA
curator
UniProt
UniProt protein ID
P29353
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling
GOA
curator
UniProt
UniProt protein ID
P29353
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
UniProt
UniProt protein ID
P29353
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains
GOA
curator
UniProt
UniProt protein ID
P29353
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Copine-III interacts with ErbB2 and promotes tumor cell migration
GOA
curator
UniProt
UniProt protein ID
P29353
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Shc and CEACAM1 interact to regulate the mitogenic action of insulin
GOA
curator
UniProt
UniProt protein ID
P29353
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
An alternative to phosphotyrosine-containing motifs for binding to an SH2 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Structure homology and interaction redundancy for discovering virus-host protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Threshold-controlled ubiquitination of the EGFR directs receptor fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Charting the molecular network of the drug target Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Charting the molecular links between driver and susceptibility genes in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
Comparative analysis of the signaling capabilities of the insulin receptor-related receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
retrieved
8 April 2019
stated in
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D000071425
subject named as
Src Homology 2 Domain-Containing, Transforming Protein 1
0 references
UniProt protein ID
P29353
0 references
Ensembl protein ID
ENSP00000357430
0 references
ENSP00000357435
0 references
ENSP00000357438
0 references
ENSP00000401303
0 references
ENSP00000357434
0 references
ENSP00000396162
0 references
ENSP00000396333
0 references
ENSP00000398441
0 references
ENSP00000398864
0 references
ENSP00000404908
0 references
 
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