Cyclin T1 (Q21116327)

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mammalian protein found in Homo sapiens
  • MLLT10/CCNT1 fusion
  • human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
  • cyclin-T1
  • CCNT1
  • CDK9-associated C-type protein
  • cyclin C-related protein
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Language Label Description Also known as
English
Cyclin T1
mammalian protein found in Homo sapiens
  • MLLT10/CCNT1 fusion
  • human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
  • cyclin-T1
  • CCNT1
  • CDK9-associated C-type protein
  • cyclin C-related protein

Statements

molecular function
protein binding
determination method
IPI
25 references
retrieved
8 April 2019
stated in
Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Identification of multiple cyclin subunits of human P-TEFb
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription
GOA
curator
UniProt
UniProt protein ID
O60563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Human mediator subunit MED26 functions as a docking site for transcription elongation factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of HIV-1 Tat complexed with human P-TEFb
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60563
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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