Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb (Q27647591)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Sonja A Dames

1

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Stephan Grzesiek

object named as

Stephan Grzesiek

6

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Matthias Geyer

object named as

Matthias Geyer

7

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author name string

André Schönichen

2

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Antje Schulte

3

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Matjaz Barboric

4

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B Matija Peterlin

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

4 September 2007

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published in

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volume

104

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issue

36

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page(s)

14312-7

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cites work

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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

20 March 2017

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A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb

20 March 2017

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Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

20 March 2017

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MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

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Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

20 March 2017

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NMR structure of a parallel homotrimeric coiled coil

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

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Controlling the elongation phase of transcription with P-TEFb

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Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

20 March 2017

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Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat

20 March 2017

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Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding

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The structure of alpha-helical coiled coils

29 September 2017

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Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes

29 September 2017

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29 September 2017

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29 September 2017

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Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb

29 September 2017

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The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.

21 January 2018

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Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef.

21 January 2018

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A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes.

21 January 2018

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An easy way to include weak alignment constraints into NMR structure calculations.

21 January 2018

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DRESS: a database of REfined solution NMR structures.

21 January 2018

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NMR assignment of the Cyclin T-binding domain of human Hexim1

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.0701848104

1 reference

release_alwc2xf4srhdvlelt5u3pv6jhe

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4705442

1 reference

1 reference

1 reference