TIR domain containing adaptor protein (Q21116674)

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mammalian protein found in Homo sapiens
  • Toll-like receptor adaptor protein
  • adapter protein wyatt
  • MyD88 adapter-like protein
  • MyD88-2
  • adaptor protein Wyatt
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • toll/interleukin-1 receptor domain-containing adapter protein
  • TIRAP
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Language Label Description Also known as
English
TIR domain containing adaptor protein
mammalian protein found in Homo sapiens
  • Toll-like receptor adaptor protein
  • adapter protein wyatt
  • MyD88 adapter-like protein
  • MyD88-2
  • adaptor protein Wyatt
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • toll/interleukin-1 receptor domain-containing adapter protein
  • TIRAP

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling
GOA
curator
UniProt
UniProt protein ID
P58753
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
MAPPIT analysis of TLR adaptor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from the Brucella Protein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
retrieved
8 April 2019
stated in
The Brucella TIR-like protein TcpB interacts with the death domain of MyD88
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58753
determination method
IPI
cell component
biological process

Identifiers

 
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