Unc-51 like autophagy activating kinase 1 (Q21116760)

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mammalian protein found in Homo sapiens
  • Unc-51-like kinase 1
  • serine/threonine-protein kinase ULK1
  • ULK1
  • hATG1
  • ATG1 autophagy related 1 homolog
  • autophagy-related protein 1 homolog
  • ATG1
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Language Label Description Also known as
English
Unc-51 like autophagy activating kinase 1
mammalian protein found in Homo sapiens
  • Unc-51-like kinase 1
  • serine/threonine-protein kinase ULK1
  • ULK1
  • hATG1
  • ATG1 autophagy related 1 homolog
  • autophagy-related protein 1 homolog
  • ATG1

Statements

molecular function
protein serine/threonine kinase activity
determination method
NAS
IDA
TAS
IEA
7 references
retrieved
27 February 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
TAS
retrieved
27 February 2018
stated in
Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
NAS
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
IEA
retrieved
27 February 2018
stated in
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
IDA
retrieved
27 February 2018
stated in
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
IDA
retrieved
27 February 2018
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385
determination method
IDA
protein binding
determination method
IPI
25 references
retrieved
8 April 2019
stated in
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
FIP200 regulates targeting of Atg16L1 to the isolation membrane
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Atg101, a novel mammalian autophagy protein interacting with Atg13
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
The association of AMPK with ULK1 regulates autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IPI
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
NAS
TAS
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
TAS
retrieved
8 April 2019
stated in
Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IEA
retrieved
8 April 2019
stated in
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism
GOA
curator
UniProt
UniProt protein ID
O75385
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IDA
retrieved
8 April 2019
stated in
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IDA
retrieved
8 April 2019
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385
determination method
IBA
cell component
biological process

Identifiers

 
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