Activating transcription factor 2 (Q21116768)

Zinc finger C2H2 superfamily

1 reference

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

cJun modulates Ggamma-globin gene expression via an upstream cAMP response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

cAMP response element binding protein binding

1 reference

8 April 2019

cJun modulates Ggamma-globin gene expression via an upstream cAMP response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

transcription coactivator activity

1 reference

10 September 2018

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

DNA-binding transcription activator activity, RNA polymerase II-specific

TAS

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

15 references

8 April 2019

Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Regulation of TIP60 by ATF2 modulates ATM activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

A comprehensive resource of interacting protein regions for refining human transcription factor networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

cis-regulatory region sequence-specific DNA binding

IPI

1 reference

8 April 2019

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

10 September 2018

cJun modulates Ggamma-globin gene expression via an upstream cAMP response element

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells

IC

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

histone acetyltransferase activity

IPI

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

1 January 2018

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

transcription factor binding

ISA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

cJun modulates Ggamma-globin gene expression via an upstream cAMP response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

DNA-binding transcription activator activity, RNA polymerase II-specific

IC

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

cJun modulates Ggamma-globin gene expression via an upstream cAMP response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Regulation of TIP60 by ATF2 modulates ATM activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

cJun modulates Ggamma-globin gene expression via an upstream cAMP response element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

mitotic intra-S DNA damage checkpoint signaling

biological process

1 reference

8 April 2019

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

response to water deprivation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

positive regulation of transforming growth factor beta2 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15336&geneProductId=UniProtKB:P15336

cellular response to DNA damage stimulus

4 references

8 April 2019

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

response to osmotic stress

1 reference

8 April 2019

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

positive regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

positive regulation of mitochondrial membrane permeability involved in apoptotic process

TAS

1 reference

8 April 2019

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

negative regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

adipose tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

positive regulation of transcription by RNA polymerase II

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

8 April 2019

IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

positive regulation of cardiac muscle myoblast proliferation

1 reference

8 April 2019

MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

positive regulation of gene expression

1 reference

8 April 2019

MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

negative regulation of angiogenesis

1 reference

8 April 2019

MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15336

has part(s)

Zinc finger C2H2-type

1 reference

Basic-leucine zipper domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D051698

subject named as

Activating Transcription Factor 2

0 references

MeSH tree code

D12.776.260.108.061.750

0 references

D12.776.930.127.061.750

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

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1 reference

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1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

language of work or name

1 reference

4 August 2016

language of work or name

1 reference

4 August 2016

language of work or name

1 reference